Detailed information of TA system TA123774

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 3144312..3144645
• Replicon: chromosome
• Accession: NZ_CP039296
• Organism: Enterococcus faecalis strain VE14089

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q82Z30
• Locus tag: E7T02_RS16660
• Protein ID: WP_002387585.1
• Coordinates: 3144312..3144455 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	3144387..3144645 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E7T02_RS16650	3139571..3139768	+	198	WP_002372618.1	putative holin-like toxin	-
E7T02_RS16655	3139958..3143716	-	3759	WP_010706868.1	WxL domain-containing protein	-
-	3144059..3144201	-	143	-	-	-
-	3144312..3144455	+	144	-	-	Toxin
E7T02_RS16660	3144312..3144455	+	144	WP_002387585.1	putative holin-like toxin	Toxin
-	3144387..3144645	-	259	-	-	Antitoxin
E7T02_RS17255	3144645..3147704	-	3060	WP_002387586.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5244.37 Da
• Isoelectric Point: 10.5719

>T123774 WP_002387585.1 NZ_CP039296:3144312-3144455 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILKVVKEDKKK

Nucleotide

• Length: 144 bp

>T123774 NZ_CP039296:3144312-3144455 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCGACTTTAATCTTCGGAATCCTAAAGGTTGTTAAAGAAGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 259 bp

>AT123774 NZ_CP039296:c3144645-3144387 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATA
ATAGCATTGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCGATTTTGTTACAA
AAAATAACCGTACTCAGTCAAAGTAAACGGTTATTTTTTCTTGTCTTCTTTAACAACCTTTAGGATTCCGAAGATTAAAG
TCGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A059MXV6

Antitoxin