Detailed information of TA system TA123767

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 3139571..3139956
• Replicon: chromosome
• Accession: NZ_CP039296
• Organism: Enterococcus faecalis strain VE14089

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U3MBY2
• Locus tag: E7T02_RS16650
• Protein ID: WP_002372618.1
• Coordinates: 3139571..3139768 (+)
• Length: 66 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	3139701..3139956 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E7T02_RS16625	3135048..3135680	-	633	WP_002358972.1	RloB family protein	-
E7T02_RS16630	3135689..3136984	-	1296	WP_002379013.1	AAA family ATPase	-
E7T02_RS16645	3137446..3139062	+	1617	WP_002379014.1	phosphatase PAP2/LCP family protein	-
E7T02_RS16650	3139571..3139768	+	198	WP_002372618.1	putative holin-like toxin	Toxin
E7T02_RS16655	3139958..3143716	-	3759	WP_010706868.1	WxL domain-containing protein	-
E7T02_RS16660	3144312..3144455	+	144	WP_002387585.1	putative holin-like toxin	-
-	3139336..3139512	-	177	-	-	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (32-65)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7516.13 Da
• Isoelectric Point: 10.5649

>T123767 WP_002372618.1 NZ_CP039296:3139571-3139768 [Enterococcus faecalis]
MCREVMAVAIQSEREVMRMHVFPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 198 bp

>T123767 NZ_CP039296:3139571-3139768 [Enterococcus faecalis]
ATGTGTAGAGAAGTTATGGCGGTGGCTATCCAATCTGAAAGAGAGGTGATGCGTATGCACGTATTTCCGAAATTCACAGA
AAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGC
TGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 256 bp

>AT123767 NZ_CP039296:c3139956-3139701 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCAGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAATGA
TAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTTATTATTTAAA
AATAACCGTGCTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAAGCA
ATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A4U3MBY2

Antitoxin