Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-dinJ/YafQ-DinJ |
Location | 474675..475209 | Replicon | chromosome |
Accession | NZ_CP039296 | ||
Organism | Enterococcus faecalis strain VE14089 |
Toxin (Protein)
Gene name | relE | Uniprot ID | R3JX52 |
Locus tag | E7T02_RS02680 | Protein ID | WP_002360769.1 |
Coordinates | 474934..475209 (+) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | dinJ | Uniprot ID | R3H6P0 |
Locus tag | E7T02_RS02675 | Protein ID | WP_002369771.1 |
Coordinates | 474675..474941 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E7T02_RS02640 | 470533..471318 | + | 786 | WP_002360778.1 | replication-relaxation family protein | - |
E7T02_RS02645 | 471324..471812 | + | 489 | WP_010710133.1 | hypothetical protein | - |
E7T02_RS02650 | 472404..472670 | + | 267 | WP_002377947.1 | hypothetical protein | - |
E7T02_RS02655 | 472703..473203 | + | 501 | WP_002360775.1 | DnaJ domain-containing protein | - |
E7T02_RS02660 | 473216..473464 | + | 249 | WP_002360773.1 | DUF3850 domain-containing protein | - |
E7T02_RS02665 | 473540..473956 | + | 417 | WP_010710134.1 | single-stranded DNA-binding protein | - |
E7T02_RS02670 | 473980..474564 | + | 585 | WP_002377949.1 | thermonuclease family protein | - |
E7T02_RS02675 | 474675..474941 | + | 267 | WP_002369771.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
E7T02_RS02680 | 474934..475209 | + | 276 | WP_002360769.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
E7T02_RS02685 | 475400..476080 | - | 681 | Protein_473 | IS6-like element IS1216 family transposase | - |
E7T02_RS02690 | 476165..477059 | + | 895 | Protein_474 | IS256 family transposase | - |
E7T02_RS02695 | 477364..478401 | - | 1038 | WP_002355369.1 | PTS sugar transporter subunit IIC | - |
E7T02_RS02700 | 478427..479365 | - | 939 | WP_002370935.1 | 2-dehydropantoate 2-reductase | - |
E7T02_RS02705 | 479493..479822 | - | 330 | WP_002358661.1 | LPXTG cell wall anchor domain-containing protein | - |
E7T02_RS02710 | 479852..480037 | + | 186 | WP_002358660.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Integrative and Conjugative Element | - | bsh / cylR2 / cylR1 / cylL / cylS / cylM / cylB | 455110..505556 | 50446 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10732.58 Da Isoelectric Point: 9.6918
>T123751 WP_002360769.1 NZ_CP039296:474934-475209 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR
Download Length: 276 bp
>T123751 NZ_CP039296:474934-475209 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9772.09 Da Isoelectric Point: 4.4791
>AT123751 WP_002369771.1 NZ_CP039296:474675-474941 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA
Download Length: 267 bp
>AT123751 NZ_CP039296:474675-474941 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M2AEA7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M2AED7 |