Detailed information of TA system TA123735

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1605682..1606217
• Replicon: chromosome
• Accession: NZ_CP039292
• Organism: Actinomyces procaprae strain dk561

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: E4J16_RS06440
• Protein ID: WP_136193031.1
• Coordinates: 1605682..1605942 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: E4J16_RS06445
• Protein ID: WP_136193030.1
• Coordinates: 1605954..1606217 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4J16_RS06415	1601465..1602946	-	1482	WP_136193036.1	sodium/proline symporter PutP	-
E4J16_RS06420	1602954..1603373	-	420	WP_136313554.1	dihydroxyacetone kinase	-
E4J16_RS06425	1603370..1604044	-	675	WP_136193034.1	dihydroxyacetone kinase subunit L	-
E4J16_RS06430	1604049..1605053	-	1005	WP_136193033.1	dihydroxyacetone kinase subunit DhaK	-
E4J16_RS06435	1605192..1605692	-	501	WP_136193032.1	holo-ACP synthase	-
E4J16_RS06440	1605682..1605942	-	261	WP_136193031.1	Txe/YoeB family addiction module toxin	Toxin
E4J16_RS06445	1605954..1606217	-	264	WP_136193030.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
E4J16_RS06450	1606214..1606867	-	654	WP_136313555.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10168.61 Da
• Isoelectric Point: 9.6240

>T123735 WP_136193031.1 NZ_CP039292:c1605942-1605682 [Actinomyces procaprae]
MRLIWSTHAWEDYLWWQAEDRRVLERVNLLLQDIQRHGSEGPGKPVALRGNLSGYWSRRITAEHRLVYRVGGDDILVVAC
RLHYGR

Nucleotide

• Length: 261 bp

>T123735 NZ_CP039292:c1605942-1605682 [Actinomyces procaprae]
ATGCGACTCATCTGGTCTACCCACGCCTGGGAGGACTACCTGTGGTGGCAGGCTGAGGATCGTCGAGTGCTCGAACGCGT
CAATCTCCTCCTCCAGGACATCCAACGGCACGGCAGCGAGGGACCCGGCAAGCCTGTGGCCCTCCGCGGCAATCTCAGCG
GCTACTGGTCGCGTCGCATCACCGCCGAGCACAGGCTCGTTTACCGGGTCGGTGGGGATGACATTCTCGTCGTTGCGTGC
AGGCTCCACTATGGGCGTTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9831.97 Da
• Isoelectric Point: 4.5686

>AT123735 WP_136193030.1 NZ_CP039292:c1606217-1605954 [Actinomyces procaprae]
MRTMTYTESRARYAQVLNDVVDDREEVVITRAGHDPAVIVSLAEYEALKETAYLLRNPANARRLLESITELEEGRGKAHE
LVNTGED

Nucleotide

• Length: 264 bp

>AT123735 NZ_CP039292:c1606217-1605954 [Actinomyces procaprae]
ATGAGGACCATGACCTACACGGAGTCCCGCGCACGCTACGCCCAAGTGCTCAATGACGTGGTGGACGACCGCGAGGAGGT
CGTCATCACTCGAGCCGGGCACGATCCCGCCGTCATCGTCTCCCTAGCTGAGTATGAGGCGCTCAAGGAGACCGCTTATC
TCCTGCGCAACCCCGCCAACGCCAGACGGCTCCTGGAGTCGATCACCGAGCTCGAGGAAGGGCGCGGCAAGGCCCACGAG
CTGGTGAACACCGGTGAGGACTGA