Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 232892..233627 Replicon chromosome
Accession NZ_CP039287
Organism Cupriavidus necator H16

Toxin (Protein)


Gene name mqsR Uniprot ID A0A7T4FXN9
Locus tag E6A55_RS01120 Protein ID WP_041687119.1
Coordinates 232892..233194 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID R7XDR2
Locus tag E6A55_RS01125 Protein ID WP_010813310.1
Coordinates 233226..233627 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E6A55_RS01100 228461..229309 + 849 WP_011614406.1 thioesterase family protein -
E6A55_RS01105 229323..230582 - 1260 WP_010813306.1 muropeptide transporter -
E6A55_RS01110 230733..231695 + 963 WP_010813307.1 M48 family metallopeptidase -
E6A55_RS01115 231766..232713 - 948 WP_010813308.1 N-acetyl-gamma-glutamyl-phosphate reductase -
E6A55_RS01120 232892..233194 + 303 WP_041687119.1 type II toxin-antitoxin system MqsR family toxin Toxin
E6A55_RS01125 233226..233627 + 402 WP_010813310.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
E6A55_RS01130 233637..234413 - 777 WP_011614408.1 exodeoxyribonuclease III -
E6A55_RS01135 234441..235127 + 687 WP_010813312.1 orotate phosphoribosyltransferase -
E6A55_RS01140 235289..236563 + 1275 WP_010813313.1 patatin-like phospholipase family protein -
E6A55_RS01145 236578..237387 - 810 WP_011614411.1 polyphosphate kinase 2 family protein -
E6A55_RS01150 237495..238361 - 867 WP_011614412.1 diaminopimelate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(7-98)

Antitoxin

Antitoxin MqsA

(3-131)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11199.02 Da        Isoelectric Point: 8.7037

>T123723 WP_041687119.1 NZ_CP039287:232892-233194 [Cupriavidus necator H16]
ICAGKGTAHDPLWRVRELIAAGRVSLTMAAFQGARNMCLTRGDVLDVVARIQPADFYKSMTTYVDHTVWQDVYRPCTSYG
AIYLKLTVTEEVLIVSFKAR

Download         Length: 303 bp

>T123723 NZ_CP039287:232892-233194 [Cupriavidus necator H16]
ATTTGCGCGGGGAAGGGAACGGCGCATGACCCGCTGTGGCGGGTCCGGGAGTTGATTGCGGCAGGGCGGGTCAGCTTGAC
GATGGCAGCGTTCCAGGGCGCCAGGAACATGTGTCTCACCCGCGGCGACGTCCTTGATGTAGTCGCCAGGATCCAGCCCG
CCGACTTCTACAAAAGCATGACGACCTACGTCGACCATACCGTCTGGCAGGATGTGTATCGCCCATGCACATCGTATGGA
GCGATATACCTGAAGCTGACGGTGACCGAGGAAGTCCTGATTGTGTCGTTCAAGGCGCGCTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14845.05 Da        Isoelectric Point: 5.8009

>AT123723 WP_010813310.1 NZ_CP039287:233226-233627 [Cupriavidus necator H16]
MRCPVCGGAELERGRKDFVYTYRGESTVIEAVLADWCAQCGEGVLGQEEEERIGPLALAFNKQVNASLVDPTYIMQVRKK
LHLDQREAAEIFGGGVNAFSRYETGRTKPPLALVKLLRLLDRHPELLEEVRAA

Download         Length: 402 bp

>AT123723 NZ_CP039287:233226-233627 [Cupriavidus necator H16]
ATGCGATGCCCGGTATGTGGAGGCGCCGAACTCGAAAGGGGGCGGAAAGACTTTGTCTATACCTACCGTGGCGAGTCCAC
GGTAATCGAAGCGGTCCTTGCCGACTGGTGTGCTCAGTGTGGAGAAGGTGTGCTGGGCCAGGAAGAGGAAGAGCGGATCG
GACCGCTGGCGCTCGCCTTCAACAAGCAAGTCAACGCCTCGCTTGTCGATCCGACTTACATCATGCAAGTCCGCAAGAAA
CTCCACCTCGACCAGCGCGAAGCCGCAGAGATCTTCGGCGGCGGGGTCAATGCATTCTCGCGCTACGAGACTGGCCGGAC
CAAGCCGCCGCTTGCGCTGGTAAAACTGCTCAGGCTGCTGGACCGCCACCCGGAACTGCTTGAGGAGGTCCGGGCGGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4FXN9

Antitoxin

Source ID Structure
AlphaFold DB A0A7T4FWF9

References