Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
Location | 232892..233627 | Replicon | chromosome |
Accession | NZ_CP039287 | ||
Organism | Cupriavidus necator H16 |
Toxin (Protein)
Gene name | mqsR | Uniprot ID | A0A7T4FXN9 |
Locus tag | E6A55_RS01120 | Protein ID | WP_041687119.1 |
Coordinates | 232892..233194 (+) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | mqsA | Uniprot ID | R7XDR2 |
Locus tag | E6A55_RS01125 | Protein ID | WP_010813310.1 |
Coordinates | 233226..233627 (+) | Length | 134 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E6A55_RS01100 | 228461..229309 | + | 849 | WP_011614406.1 | thioesterase family protein | - |
E6A55_RS01105 | 229323..230582 | - | 1260 | WP_010813306.1 | muropeptide transporter | - |
E6A55_RS01110 | 230733..231695 | + | 963 | WP_010813307.1 | M48 family metallopeptidase | - |
E6A55_RS01115 | 231766..232713 | - | 948 | WP_010813308.1 | N-acetyl-gamma-glutamyl-phosphate reductase | - |
E6A55_RS01120 | 232892..233194 | + | 303 | WP_041687119.1 | type II toxin-antitoxin system MqsR family toxin | Toxin |
E6A55_RS01125 | 233226..233627 | + | 402 | WP_010813310.1 | type II toxin-antitoxin system MqsA family antitoxin | Antitoxin |
E6A55_RS01130 | 233637..234413 | - | 777 | WP_011614408.1 | exodeoxyribonuclease III | - |
E6A55_RS01135 | 234441..235127 | + | 687 | WP_010813312.1 | orotate phosphoribosyltransferase | - |
E6A55_RS01140 | 235289..236563 | + | 1275 | WP_010813313.1 | patatin-like phospholipase family protein | - |
E6A55_RS01145 | 236578..237387 | - | 810 | WP_011614411.1 | polyphosphate kinase 2 family protein | - |
E6A55_RS01150 | 237495..238361 | - | 867 | WP_011614412.1 | diaminopimelate epimerase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11199.02 Da Isoelectric Point: 8.7037
>T123723 WP_041687119.1 NZ_CP039287:232892-233194 [Cupriavidus necator H16]
ICAGKGTAHDPLWRVRELIAAGRVSLTMAAFQGARNMCLTRGDVLDVVARIQPADFYKSMTTYVDHTVWQDVYRPCTSYG
AIYLKLTVTEEVLIVSFKAR
ICAGKGTAHDPLWRVRELIAAGRVSLTMAAFQGARNMCLTRGDVLDVVARIQPADFYKSMTTYVDHTVWQDVYRPCTSYG
AIYLKLTVTEEVLIVSFKAR
Download Length: 303 bp
>T123723 NZ_CP039287:232892-233194 [Cupriavidus necator H16]
ATTTGCGCGGGGAAGGGAACGGCGCATGACCCGCTGTGGCGGGTCCGGGAGTTGATTGCGGCAGGGCGGGTCAGCTTGAC
GATGGCAGCGTTCCAGGGCGCCAGGAACATGTGTCTCACCCGCGGCGACGTCCTTGATGTAGTCGCCAGGATCCAGCCCG
CCGACTTCTACAAAAGCATGACGACCTACGTCGACCATACCGTCTGGCAGGATGTGTATCGCCCATGCACATCGTATGGA
GCGATATACCTGAAGCTGACGGTGACCGAGGAAGTCCTGATTGTGTCGTTCAAGGCGCGCTAG
ATTTGCGCGGGGAAGGGAACGGCGCATGACCCGCTGTGGCGGGTCCGGGAGTTGATTGCGGCAGGGCGGGTCAGCTTGAC
GATGGCAGCGTTCCAGGGCGCCAGGAACATGTGTCTCACCCGCGGCGACGTCCTTGATGTAGTCGCCAGGATCCAGCCCG
CCGACTTCTACAAAAGCATGACGACCTACGTCGACCATACCGTCTGGCAGGATGTGTATCGCCCATGCACATCGTATGGA
GCGATATACCTGAAGCTGACGGTGACCGAGGAAGTCCTGATTGTGTCGTTCAAGGCGCGCTAG
Antitoxin
Download Length: 134 a.a. Molecular weight: 14845.05 Da Isoelectric Point: 5.8009
>AT123723 WP_010813310.1 NZ_CP039287:233226-233627 [Cupriavidus necator H16]
MRCPVCGGAELERGRKDFVYTYRGESTVIEAVLADWCAQCGEGVLGQEEEERIGPLALAFNKQVNASLVDPTYIMQVRKK
LHLDQREAAEIFGGGVNAFSRYETGRTKPPLALVKLLRLLDRHPELLEEVRAA
MRCPVCGGAELERGRKDFVYTYRGESTVIEAVLADWCAQCGEGVLGQEEEERIGPLALAFNKQVNASLVDPTYIMQVRKK
LHLDQREAAEIFGGGVNAFSRYETGRTKPPLALVKLLRLLDRHPELLEEVRAA
Download Length: 402 bp
>AT123723 NZ_CP039287:233226-233627 [Cupriavidus necator H16]
ATGCGATGCCCGGTATGTGGAGGCGCCGAACTCGAAAGGGGGCGGAAAGACTTTGTCTATACCTACCGTGGCGAGTCCAC
GGTAATCGAAGCGGTCCTTGCCGACTGGTGTGCTCAGTGTGGAGAAGGTGTGCTGGGCCAGGAAGAGGAAGAGCGGATCG
GACCGCTGGCGCTCGCCTTCAACAAGCAAGTCAACGCCTCGCTTGTCGATCCGACTTACATCATGCAAGTCCGCAAGAAA
CTCCACCTCGACCAGCGCGAAGCCGCAGAGATCTTCGGCGGCGGGGTCAATGCATTCTCGCGCTACGAGACTGGCCGGAC
CAAGCCGCCGCTTGCGCTGGTAAAACTGCTCAGGCTGCTGGACCGCCACCCGGAACTGCTTGAGGAGGTCCGGGCGGCCT
GA
ATGCGATGCCCGGTATGTGGAGGCGCCGAACTCGAAAGGGGGCGGAAAGACTTTGTCTATACCTACCGTGGCGAGTCCAC
GGTAATCGAAGCGGTCCTTGCCGACTGGTGTGCTCAGTGTGGAGAAGGTGTGCTGGGCCAGGAAGAGGAAGAGCGGATCG
GACCGCTGGCGCTCGCCTTCAACAAGCAAGTCAACGCCTCGCTTGTCGATCCGACTTACATCATGCAAGTCCGCAAGAAA
CTCCACCTCGACCAGCGCGAAGCCGCAGAGATCTTCGGCGGCGGGGTCAATGCATTCTCGCGCTACGAGACTGGCCGGAC
CAAGCCGCCGCTTGCGCTGGTAAAACTGCTCAGGCTGCTGGACCGCCACCCGGAACTGCTTGAGGAGGTCCGGGCGGCCT
GA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7T4FXN9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7T4FWF9 |