Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2429931..2430115 Replicon chromosome
Accession NZ_CP039167
Organism Staphylococcus aureus strain R50

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag E1952_RS12585 Protein ID WP_000482647.1
Coordinates 2430008..2430115 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2429931..2429991 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1952_RS12570 2425382..2425549 - 168 Protein_2389 hypothetical protein -
E1952_RS12575 2425780..2427513 - 1734 WP_000486506.1 ABC transporter ATP-binding protein/permease -
E1952_RS12580 2427538..2429301 - 1764 WP_001064814.1 ABC transporter ATP-binding protein/permease -
- 2429931..2429991 + 61 - - Antitoxin
E1952_RS12585 2430008..2430115 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
E1952_RS12590 2430249..2430635 - 387 WP_000779360.1 flippase GtxA -
E1952_RS12595 2430893..2432035 + 1143 WP_001837638.1 glycerate kinase -
E1952_RS12600 2432095..2432754 + 660 WP_000831301.1 membrane protein -
E1952_RS12605 2432936..2434147 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
E1952_RS12610 2434270..2434743 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T123633 WP_000482647.1 NZ_CP039167:c2430115-2430008 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T123633 NZ_CP039167:c2430115-2430008 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT123633 NZ_CP039167:2429931-2429991 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References