Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2404619..2405136 Replicon chromosome
Accession NZ_CP039167
Organism Staphylococcus aureus strain R50

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E1952_RS12445 Protein ID WP_000113262.1
Coordinates 2404619..2404885 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E1952_RS12450 Protein ID WP_000584499.1
Coordinates 2404885..2405136 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1952_RS12420 2400043..2400579 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
E1952_RS12425 2400813..2401637 - 825 WP_000594630.1 formate/nitrite transporter family protein -
E1952_RS12430 2401853..2402038 - 186 WP_000230293.1 hypothetical protein -
E1952_RS12435 2402122..2402589 - 468 WP_000153344.1 SRPBCC domain-containing protein -
E1952_RS12440 2402775..2404325 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E1952_RS12445 2404619..2404885 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E1952_RS12450 2404885..2405136 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E1952_RS12455 2405301..2405402 - 102 WP_031867537.1 hypothetical protein -
E1952_RS12460 2405409..2406008 - 600 WP_000162799.1 DsbA family protein -
E1952_RS12465 2406027..2406389 - 363 WP_000819843.1 DUF4467 domain-containing protein -
E1952_RS12470 2406644..2407894 + 1251 WP_001012219.1 FemA/FemB family glycyltransferase FmhA -
E1952_RS12475 2407991..2408722 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E1952_RS12480 2408719..2409438 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T123632 WP_000113262.1 NZ_CP039167:c2404885-2404619 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T123632 NZ_CP039167:c2404885-2404619 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT123632 WP_000584499.1 NZ_CP039167:c2405136-2404885 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT123632 NZ_CP039167:c2405136-2404885 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References