Detailed information of TA system TA123620

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1517360..1517660
• Replicon: chromosome
• Accession: NZ_CP039167
• Organism: Staphylococcus aureus strain R50

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: E1952_RS07585
• Protein ID: WP_073391028.1
• Coordinates: 1517439..1517660 (-)
• Length: 74 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1517360..1517415 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1952_RS07555	1512764..1512949	-	186	WP_000470336.1	hypothetical protein	-
E1952_RS07560	1513198..1514181	-	984	WP_024937002.1	Panton-Valentine bi-component leukocidin subunit F	-
E1952_RS07565	1514177..1515115	-	939	WP_000239544.1	Panton-Valentine bi-component leukocidin subunit S	-
E1952_RS07570	1515505..1516959	-	1455	WP_000909197.1	N-acetylmuramoyl-L-alanine amidase	-
E1952_RS07575	1516970..1517272	-	303	WP_000992284.1	phage holin	-
E1952_RS07580	1517323..1517430	+	108	WP_031867548.1	hypothetical protein	-
-	1517352..1517491	+	140	NuclAT_0	-	-
-	1517352..1517491	+	140	NuclAT_0	-	-
-	1517352..1517491	+	140	NuclAT_0	-	-
-	1517352..1517491	+	140	NuclAT_0	-	-
-	1517360..1517415	+	56	-	-	Antitoxin
E1952_RS07585	1517439..1517660	-	222	WP_073391028.1	putative holin-like toxin	Toxin
E1952_RS07590	1517769..1518542	-	774	WP_000750407.1	staphylococcal enterotoxin type A	-
E1952_RS07595	1518963..1519337	-	375	WP_000340977.1	hypothetical protein	-
E1952_RS07600	1519393..1519680	-	288	WP_001262620.1	hypothetical protein	-
E1952_RS07605	1519726..1519878	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV / sea / gnd	1512764..1578737	65973

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8689.56 Da
• Isoelectric Point: 10.7294

>T123620 WP_073391028.1 NZ_CP039167:c1517660-1517439 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKKITIANFGWFRWLNGY

Nucleotide

• Length: 222 bp

>T123620 NZ_CP039167:c1517660-1517439 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAAATAACCATCGCTAACTTTGGTTGGTTTCGATGGTTAAATGGTTATTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT123620 NZ_CP039167:1517360-1517415 [Staphylococcus aureus]
AAAAAGGGCAACATACGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin