Detailed information of TA system TA123617

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 1516970..1517496
• Replicon: chromosome
• Accession: NZ_CP039167
• Organism: Staphylococcus aureus strain R50

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: E1952_RS07575
• Protein ID: WP_000992284.1
• Coordinates: 1516970..1517272 (-)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1517321..1517496 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1952_RS07555	1512764..1512949	-	186	WP_000470336.1	hypothetical protein	-
E1952_RS07560	1513198..1514181	-	984	WP_024937002.1	Panton-Valentine bi-component leukocidin subunit F	-
E1952_RS07565	1514177..1515115	-	939	WP_000239544.1	Panton-Valentine bi-component leukocidin subunit S	-
E1952_RS07570	1515505..1516959	-	1455	WP_000909197.1	N-acetylmuramoyl-L-alanine amidase	-
E1952_RS07575	1516970..1517272	-	303	WP_000992284.1	phage holin	Toxin
-	1517321..1517496	+	176	-	-	Antitoxin
E1952_RS07585	1517439..1517660	-	222	WP_073391028.1	putative holin-like toxin	-
E1952_RS07590	1517769..1518542	-	774	WP_000750407.1	staphylococcal enterotoxin type A	-
E1952_RS07595	1518963..1519337	-	375	WP_000340977.1	hypothetical protein	-
E1952_RS07600	1519393..1519680	-	288	WP_001262620.1	hypothetical protein	-
E1952_RS07605	1519726..1519878	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV / sea / gnd	1512764..1578737	65973

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (2-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11159.91 Da
• Isoelectric Point: 9.8680

>T123617 WP_000992284.1 NZ_CP039167:c1517272-1516970 [Staphylococcus aureus]
MNAKVITRYIVLILALVNQFLANKGISPIPVDEESVSSIILTVVALYTTYKDNPTSQEGKWANQKLKKYKAENKYRKATG
QAPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T123617 NZ_CP039167:c1517272-1516970 [Staphylococcus aureus]
ATGAATGCAAAAGTAATAACAAGATATATAGTATTAATTTTAGCGTTAGTCAATCAGTTTTTAGCGAATAAAGGTATAAG
TCCGATACCAGTAGATGAAGAAAGTGTTTCATCGATTATCTTAACAGTTGTTGCTTTATATACTACATATAAAGATAATC
CAACATCTCAAGAAGGTAAATGGGCAAATCAAAAGCTAAAGAAATATAAAGCTGAAAACAAGTATAGAAAAGCAACAGGG
CAAGCGCCAATTAAAGAAGTAATGACACCTACGAATATGAACGACACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 176 bp

>AT123617 NZ_CP039167:1517321-1517496 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATTTAGAAAAAGGGCAACATACGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAACCAAAGTTAGCGAT
GGTTATTTTTTTATTG

Structures

Antitoxin