123612

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2377530..2377714 Replicon chromosome
Accession NZ_CP039162
Organism Staphylococcus aureus strain Lr12

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag E1950_RS12175 Protein ID WP_000482652.1
Coordinates 2377607..2377714 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2377530..2377590 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1950_RS12160 2372985..2373152 - 168 Protein_2330 hypothetical protein -
E1950_RS12165 2373383..2375116 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
E1950_RS12170 2375141..2376904 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2377530..2377590 + 61 - - Antitoxin
E1950_RS12175 2377607..2377714 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
E1950_RS12180 2377848..2378234 - 387 WP_000779360.1 flippase GtxA -
E1950_RS12185 2378502..2379644 + 1143 WP_103152217.1 glycerate kinase -
E1950_RS12190 2379704..2380363 + 660 WP_000831298.1 membrane protein -
E1950_RS12195 2380545..2381756 + 1212 WP_103152218.1 multidrug effflux MFS transporter -
E1950_RS12200 2381879..2382352 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T123612 WP_000482652.1 NZ_CP039162:c2377714-2377607 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T123612 NZ_CP039162:c2377714-2377607 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT123612 NZ_CP039162:2377530-2377590 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References