Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2352035..2352552 Replicon chromosome
Accession NZ_CP039162
Organism Staphylococcus aureus strain Lr12

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag E1950_RS12035 Protein ID WP_000113265.1
Coordinates 2352035..2352301 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E1950_RS12040 Protein ID WP_000584499.1
Coordinates 2352301..2352552 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1950_RS12005 2347463..2347999 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
E1950_RS12010 2348233..2349057 - 825 WP_000572038.1 formate/nitrite transporter family protein -
E1950_RS12015 2349274..2349456 - 183 WP_000230292.1 hypothetical protein -
E1950_RS12020 2349540..2350007 - 468 WP_000153347.1 SRPBCC domain-containing protein -
E1950_RS12025 2350193..2351740 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E1950_RS12030 2351929..2352000 - 72 Protein_2305 hypothetical protein -
E1950_RS12035 2352035..2352301 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
E1950_RS12040 2352301..2352552 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E1950_RS12045 2352717..2352818 - 102 Protein_2308 hypothetical protein -
E1950_RS12050 2352825..2353424 - 600 WP_000162810.1 DsbA family protein -
E1950_RS12055 2353443..2353805 - 363 WP_000819843.1 DUF4467 domain-containing protein -
E1950_RS12060 2354060..2355310 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
E1950_RS12065 2355407..2356138 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E1950_RS12070 2356135..2356854 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T123611 WP_000113265.1 NZ_CP039162:c2352301-2352035 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T123611 NZ_CP039162:c2352301-2352035 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT123611 WP_000584499.1 NZ_CP039162:c2352552-2352301 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT123611 NZ_CP039162:c2352552-2352301 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References