Detailed information of TA system TA123605

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1924463..1924762
• Replicon: chromosome
• Accession: NZ_CP039162
• Organism: Staphylococcus aureus strain Lr12

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: E1950_RS09685
• Protein ID: WP_072353918.1
• Coordinates: 1924586..1924762 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1924463..1924518 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1950_RS09625	1920021..1920200	+	180	WP_000669791.1	hypothetical protein	-
E1950_RS09635	1920511..1920771	+	261	WP_001791826.1	hypothetical protein	-
E1950_RS09640	1920824..1921174	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
E1950_RS09645	1921685..1922020	-	336	Protein_1853	SH3 domain-containing protein	-
E1950_RS09665	1922671..1923162	-	492	WP_000920038.1	staphylokinase	-
E1950_RS09670	1923353..1924108	-	756	WP_000861038.1	CHAP domain-containing protein	-
E1950_RS09675	1924120..1924374	-	255	WP_000611512.1	phage holin	-
E1950_RS09680	1924426..1924533	+	108	WP_001791821.1	hypothetical protein	-
-	1924455..1924594	+	140	NuclAT_0	-	-
-	1924455..1924594	+	140	NuclAT_0	-	-
-	1924455..1924594	+	140	NuclAT_0	-	-
-	1924455..1924594	+	140	NuclAT_0	-	-
-	1924463..1924518	+	56	-	-	Antitoxin
E1950_RS09685	1924586..1924762	-	177	WP_072353918.1	putative holin-like toxin	Toxin
E1950_RS09690	1924905..1925279	-	375	WP_000340977.1	hypothetical protein	-
E1950_RS09695	1925335..1925622	-	288	WP_001262620.1	hypothetical protein	-
E1950_RS09700	1925668..1925820	-	153	WP_001000058.1	hypothetical protein	-
E1950_RS09705	1925813..1929595	-	3783	WP_000582128.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1920824..1970651	49827

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T123605 WP_072353918.1 NZ_CP039162:c1924762-1924586 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T123605 NZ_CP039162:c1924762-1924586 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT123605 NZ_CP039162:1924463-1924518 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin