Detailed information of TA system TA123601

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1781939..1782119
• Replicon: chromosome
• Accession: NZ_CP039162
• Organism: Staphylococcus aureus strain Lr12

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: E1950_RS08820
• Protein ID: WP_001801861.1
• Coordinates: 1781939..1782034 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1782062..1782119 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1950_RS08790	1777102..1777752	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
E1950_RS08795	1777833..1778828	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
E1950_RS08800	1778903..1779529	+	627	WP_000669024.1	hypothetical protein	-
E1950_RS08805	1779570..1779911	+	342	WP_000627540.1	DUF3969 family protein	-
E1950_RS08810	1780012..1780584	+	573	WP_000414216.1	hypothetical protein	-
E1950_RS08815	1780782..1781794	-	1013	Protein_1702	IS3 family transposase	-
E1950_RS08820	1781939..1782034	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1782062..1782119	-	58	-	-	Antitoxin
E1950_RS08825	1782157..1782258	+	102	WP_001792025.1	hypothetical protein	-
E1950_RS08830	1782236..1782397	-	162	Protein_1705	transposase	-
E1950_RS08835	1782388..1782882	-	495	Protein_1706	transposase	-
E1950_RS08840	1783334..1784089	-	756	Protein_1707	restriction endonuclease subunit S	-
E1950_RS08850	1784287..1784421	-	135	WP_069479482.1	hypothetical protein	-
E1950_RS08855	1784484..1785203	-	720	WP_001038752.1	serine protease SplF	-
E1950_RS08860	1785305..1785412	+	108	WP_011447030.1	hypothetical protein	-
E1950_RS08865	1785361..1786080	-	720	WP_001038704.1	serine protease SplD	-
E1950_RS08870	1786201..1786920	-	720	WP_001038872.1	serine protease SplC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T123601 WP_001801861.1 NZ_CP039162:1781939-1782034 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T123601 NZ_CP039162:1781939-1782034 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT123601 NZ_CP039162:c1782119-1782062 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin