Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2398177..2398361 Replicon chromosome
Accession NZ_CP039160
Organism Staphylococcus aureus strain Lr6

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag E1949_RS12310 Protein ID WP_000482647.1
Coordinates 2398254..2398361 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2398177..2398237 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1949_RS12295 2393628..2393795 - 168 Protein_2328 hypothetical protein -
E1949_RS12300 2394026..2395759 - 1734 WP_000486506.1 ABC transporter ATP-binding protein/permease -
E1949_RS12305 2395784..2397547 - 1764 WP_001064814.1 ABC transporter ATP-binding protein/permease -
- 2398177..2398237 + 61 - - Antitoxin
E1949_RS12310 2398254..2398361 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
E1949_RS12315 2398495..2398881 - 387 WP_000779360.1 flippase GtxA -
E1949_RS12320 2399139..2400281 + 1143 WP_001837638.1 glycerate kinase -
E1949_RS12325 2400341..2401000 + 660 WP_000831301.1 membrane protein -
E1949_RS12330 2401182..2402393 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
E1949_RS12335 2402516..2402989 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T123597 WP_000482647.1 NZ_CP039160:c2398361-2398254 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T123597 NZ_CP039160:c2398361-2398254 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT123597 NZ_CP039160:2398177-2398237 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References