Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprG3-SprA2AS/-
Location 2118707..2118923 Replicon chromosome
Accession NZ_CP039160
Organism Staphylococcus aureus strain Lr6

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag E1949_RS10830 Protein ID WP_001802298.1
Coordinates 2118819..2118923 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2118707..2118762 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1949_RS10810 2114913..2115578 - 666 WP_001024095.1 SDR family oxidoreductase -
E1949_RS10815 2115730..2116050 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
E1949_RS10820 2116052..2117029 + 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
E1949_RS10825 2117295..2118386 + 1092 WP_000495669.1 hypothetical protein -
- 2118707..2118762 + 56 - - Antitoxin
E1949_RS10830 2118819..2118923 - 105 WP_001802298.1 hypothetical protein Toxin
E1949_RS10840 2119603..2119761 + 159 WP_001792784.1 hypothetical protein -
E1949_RS10850 2120419..2121276 - 858 WP_000370925.1 Cof-type HAD-IIB family hydrolase -
E1949_RS10855 2121344..2122126 - 783 WP_000908182.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T123595 WP_001802298.1 NZ_CP039160:c2118923-2118819 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T123595 NZ_CP039160:c2118923-2118819 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT123595 NZ_CP039160:2118707-2118762 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References