Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 1495452..1495875 | Replicon | chromosome |
| Accession | NZ_CP039160 | ||
| Organism | Staphylococcus aureus strain Lr6 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | E1949_RS07395 | Protein ID | WP_001837494.1 |
| Coordinates | 1495624..1495875 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A0E0VQM8 |
| Locus tag | E1949_RS07390 | Protein ID | WP_000028422.1 |
| Coordinates | 1495452..1495634 (-) | Length | 61 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E1949_RS07340 | 1490595..1492256 | - | 1662 | WP_000625088.1 | terminase large subunit | - |
| E1949_RS07345 | 1492253..1492597 | - | 345 | WP_000402904.1 | hypothetical protein | - |
| E1949_RS07350 | 1492728..1493027 | - | 300 | WP_000988336.1 | HNH endonuclease | - |
| E1949_RS07355 | 1493259..1493675 | - | 417 | WP_000590122.1 | hypothetical protein | - |
| E1949_RS07360 | 1493703..1493903 | - | 201 | WP_000265042.1 | DUF1514 family protein | - |
| E1949_RS07365 | 1493903..1494052 | - | 150 | WP_000595265.1 | transcriptional activator RinB | - |
| E1949_RS07370 | 1494049..1494435 | - | 387 | WP_000592207.1 | hypothetical protein | - |
| E1949_RS07375 | 1494432..1494638 | - | 207 | WP_000195803.1 | DUF1381 domain-containing protein | - |
| E1949_RS07380 | 1494635..1494880 | - | 246 | WP_001282074.1 | hypothetical protein | - |
| E1949_RS07385 | 1494917..1495459 | - | 543 | WP_000185660.1 | dUTP pyrophosphatase | - |
| E1949_RS07390 | 1495452..1495634 | - | 183 | WP_000028422.1 | hypothetical protein | Antitoxin |
| E1949_RS07395 | 1495624..1495875 | - | 252 | WP_001837494.1 | DUF1024 family protein | Toxin |
| E1949_RS07400 | 1495868..1496152 | - | 285 | WP_001105620.1 | hypothetical protein | - |
| E1949_RS07405 | 1496149..1496598 | - | 450 | WP_000982708.1 | hypothetical protein | - |
| E1949_RS07410 | 1496663..1496905 | - | 243 | WP_000131386.1 | phi PVL orf 51-like protein | - |
| E1949_RS07415 | 1496909..1497265 | - | 357 | WP_000029376.1 | hypothetical protein | - |
| E1949_RS07420 | 1497266..1497451 | - | 186 | WP_001187245.1 | DUF3113 family protein | - |
| E1949_RS07425 | 1497456..1497860 | - | 405 | WP_000049795.1 | DUF1064 domain-containing protein | - |
| E1949_RS07430 | 1497870..1498091 | - | 222 | WP_001123695.1 | DUF3269 family protein | - |
| E1949_RS07435 | 1498105..1498263 | - | 159 | WP_000256597.1 | hypothetical protein | - |
| E1949_RS07440 | 1498257..1499036 | - | 780 | WP_000803063.1 | ATP-binding protein | - |
| E1949_RS07445 | 1499046..1499816 | - | 771 | WP_000190254.1 | conserved phage C-terminal domain-containing protein | - |
| E1949_RS07450 | 1499882..1500163 | + | 282 | WP_000414755.1 | hypothetical protein | - |
| E1949_RS14270 | 1500156..1500305 | - | 150 | WP_001081076.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lukF-PV / lukS-PV / sea / gnd | 1464345..1534066 | 69721 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9350.20 Da Isoelectric Point: 3.9022
>T123588 WP_001837494.1 NZ_CP039160:c1495875-1495624 [Staphylococcus aureus]
MDNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH
MDNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH
Download Length: 252 bp
>T123588 NZ_CP039160:c1495875-1495624 [Staphylococcus aureus]
ATGGATAACCGTGAACAAATAGAACAATCAGTGATCAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG
ATGGATAACCGTGAACAAATAGAACAATCAGTGATCAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG
Antitoxin
Download Length: 61 a.a. Molecular weight: 6741.63 Da Isoelectric Point: 4.2658
>AT123588 WP_000028422.1 NZ_CP039160:c1495634-1495452 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND
Download Length: 183 bp
>AT123588 NZ_CP039160:c1495634-1495452 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|