Detailed information of TA system TA123584

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1471883..1472183
• Replicon: chromosome
• Accession: NZ_CP039160
• Organism: Staphylococcus aureus strain Lr6

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: E1949_RS07245
• Protein ID: WP_073391028.1
• Coordinates: 1471962..1472183 (-)
• Length: 74 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1471883..1471938 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1949_RS07215	1467287..1467472	-	186	WP_000470336.1	hypothetical protein	-
E1949_RS07220	1467721..1468704	-	984	WP_024937002.1	Panton-Valentine bi-component leukocidin subunit F	-
E1949_RS07225	1468700..1469638	-	939	WP_000239544.1	Panton-Valentine bi-component leukocidin subunit S	-
E1949_RS07230	1470028..1471482	-	1455	WP_000909197.1	N-acetylmuramoyl-L-alanine amidase	-
E1949_RS07235	1471493..1471795	-	303	WP_000992284.1	phage holin	-
E1949_RS07240	1471846..1471953	+	108	WP_031867548.1	hypothetical protein	-
-	1471875..1472014	+	140	NuclAT_0	-	-
-	1471875..1472014	+	140	NuclAT_0	-	-
-	1471875..1472014	+	140	NuclAT_0	-	-
-	1471875..1472014	+	140	NuclAT_0	-	-
-	1471883..1471938	+	56	-	-	Antitoxin
E1949_RS07245	1471962..1472183	-	222	WP_073391028.1	putative holin-like toxin	Toxin
E1949_RS07250	1472292..1473065	-	774	WP_000750407.1	staphylococcal enterotoxin type A	-
E1949_RS07255	1473486..1473860	-	375	WP_000340977.1	hypothetical protein	-
E1949_RS07260	1473916..1474203	-	288	WP_001262620.1	hypothetical protein	-
E1949_RS07265	1474249..1474401	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV / sea / gnd	1464345..1534066	69721

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8689.56 Da
• Isoelectric Point: 10.7294

>T123584 WP_073391028.1 NZ_CP039160:c1472183-1471962 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKKITIANFGWFRWLNGY

Nucleotide

• Length: 222 bp

>T123584 NZ_CP039160:c1472183-1471962 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAAATAACCATCGCTAACTTTGGTTGGTTTCGATGGTTAAATGGTTATTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT123584 NZ_CP039160:1471883-1471938 [Staphylococcus aureus]
AAAAAGGGCAACATACGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin