Detailed information of TA system TA123581

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 1471493..1472019
• Replicon: chromosome
• Accession: NZ_CP039160
• Organism: Staphylococcus aureus strain Lr6

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: E1949_RS07235
• Protein ID: WP_000992284.1
• Coordinates: 1471493..1471795 (-)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1471844..1472019 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1949_RS07215	1467287..1467472	-	186	WP_000470336.1	hypothetical protein	-
E1949_RS07220	1467721..1468704	-	984	WP_024937002.1	Panton-Valentine bi-component leukocidin subunit F	-
E1949_RS07225	1468700..1469638	-	939	WP_000239544.1	Panton-Valentine bi-component leukocidin subunit S	-
E1949_RS07230	1470028..1471482	-	1455	WP_000909197.1	N-acetylmuramoyl-L-alanine amidase	-
E1949_RS07235	1471493..1471795	-	303	WP_000992284.1	phage holin	Toxin
-	1471844..1472019	+	176	-	-	Antitoxin
E1949_RS07245	1471962..1472183	-	222	WP_073391028.1	putative holin-like toxin	-
E1949_RS07250	1472292..1473065	-	774	WP_000750407.1	staphylococcal enterotoxin type A	-
E1949_RS07255	1473486..1473860	-	375	WP_000340977.1	hypothetical protein	-
E1949_RS07260	1473916..1474203	-	288	WP_001262620.1	hypothetical protein	-
E1949_RS07265	1474249..1474401	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV / sea / gnd	1464345..1534066	69721

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (2-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11159.91 Da
• Isoelectric Point: 9.8680

>T123581 WP_000992284.1 NZ_CP039160:c1471795-1471493 [Staphylococcus aureus]
MNAKVITRYIVLILALVNQFLANKGISPIPVDEESVSSIILTVVALYTTYKDNPTSQEGKWANQKLKKYKAENKYRKATG
QAPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T123581 NZ_CP039160:c1471795-1471493 [Staphylococcus aureus]
ATGAATGCAAAAGTAATAACAAGATATATAGTATTAATTTTAGCGTTAGTCAATCAGTTTTTAGCGAATAAAGGTATAAG
TCCGATACCAGTAGATGAAGAAAGTGTTTCATCGATTATCTTAACAGTTGTTGCTTTATATACTACATATAAAGATAATC
CAACATCTCAAGAAGGTAAATGGGCAAATCAAAAGCTAAAGAAATATAAAGCTGAAAACAAGTATAGAAAAGCAACAGGG
CAAGCGCCAATTAAAGAAGTAATGACACCTACGAATATGAACGACACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 176 bp

>AT123581 NZ_CP039160:1471844-1472019 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATTTAGAAAAAGGGCAACATACGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAACCAAAGTTAGCGAT
GGTTATTTTTTTATTG

Structures

Antitoxin