123576

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2580924..2581108 Replicon chromosome
Accession NZ_CP039156
Organism Staphylococcus aureus strain WCUH29

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag E5491_RS13605 Protein ID WP_000482652.1
Coordinates 2581001..2581108 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2580924..2580984 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5491_RS13580 2576379..2576546 - 168 Protein_2536 hypothetical protein -
E5491_RS13590 2576777..2578510 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
E5491_RS13595 2578535..2580298 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2580924..2580984 + 61 - - Antitoxin
E5491_RS13605 2581001..2581108 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
E5491_RS13610 2581242..2581628 - 387 WP_000779360.1 flippase GtxA -
E5491_RS13615 2581896..2583038 + 1143 WP_001176863.1 glycerate kinase -
E5491_RS13620 2583098..2583757 + 660 WP_000831298.1 membrane protein -
E5491_RS13625 2583939..2585150 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
E5491_RS13630 2585273..2585746 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T123576 WP_000482652.1 NZ_CP039156:c2581108-2581001 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T123576 NZ_CP039156:c2581108-2581001 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT123576 NZ_CP039156:2580924-2580984 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References