Detailed information of TA system TA123568

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2124765..2125072
• Replicon: chromosome
• Accession: NZ_CP039156
• Organism: Staphylococcus aureus strain WCUH29

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: E5491_RS11080
• Protein ID: WP_072482930.1
• Coordinates: 2124896..2125072 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2124765..2124904 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5491_RS11030	2120106..2120366	+	261	WP_001791826.1	hypothetical protein	-
E5491_RS11035	2120419..2120769	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
E5491_RS11040	2121452..2121901	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
E5491_RS11045	2121996..2122330	-	335	Protein_2063	SH3 domain-containing protein	-
E5491_RS11060	2122981..2123472	-	492	WP_000920042.1	staphylokinase	-
E5491_RS11065	2123663..2124418	-	756	WP_000861040.1	CHAP domain-containing protein	-
E5491_RS11070	2124430..2124684	-	255	WP_000611512.1	phage holin	-
E5491_RS11075	2124736..2124843	+	108	Protein_2067	hypothetical protein	-
-	2124765..2124904	+	140	NuclAT_0	-	Antitoxin
-	2124765..2124904	+	140	NuclAT_0	-	Antitoxin
-	2124765..2124904	+	140	NuclAT_0	-	Antitoxin
-	2124765..2124904	+	140	NuclAT_0	-	Antitoxin
E5491_RS11080	2124896..2125072	-	177	WP_072482930.1	putative holin-like toxin	Toxin
E5491_RS11085	2125181..2125954	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
E5491_RS11090	2126327..2126701	-	375	WP_000340977.1	hypothetical protein	-
E5491_RS11095	2126757..2127044	-	288	WP_001262621.1	hypothetical protein	-
E5491_RS11100	2127090..2127242	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / sea / hlb / groEL	2116923..2174844	57921

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T123568 WP_072482930.1 NZ_CP039156:c2125072-2124896 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T123568 NZ_CP039156:c2125072-2124896 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT123568 NZ_CP039156:2124765-2124904 [Staphylococcus aureus]
ATATATATAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin