Detailed information of TA system TA123565

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1927927..1928107
• Replicon: chromosome
• Accession: NZ_CP039156
• Organism: Staphylococcus aureus strain WCUH29

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: E5491_RS09705
• Protein ID: WP_001801861.1
• Coordinates: 1927927..1928022 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1928050..1928107 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5491_RS09675	1923090..1923740	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
E5491_RS09680	1923821..1924816	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
E5491_RS09685	1924891..1925517	+	627	WP_000669024.1	hypothetical protein	-
E5491_RS09690	1925558..1925899	+	342	WP_000627540.1	DUF3969 family protein	-
E5491_RS09695	1926000..1926572	+	573	WP_000414216.1	hypothetical protein	-
E5491_RS09700	1926770..1927782	-	1013	Protein_1841	IS3 family transposase	-
E5491_RS09705	1927927..1928022	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1928050..1928107	-	58	-	-	Antitoxin
E5491_RS09710	1928145..1928246	+	102	WP_001792025.1	hypothetical protein	-
E5491_RS09715	1928224..1928385	-	162	Protein_1844	transposase	-
E5491_RS09720	1928376..1928870	-	495	Protein_1845	transposase	-
E5491_RS09725	1929322..1930551	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
E5491_RS09730	1930544..1932100	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
E5491_RS09735	1932264..1932398	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1922332..1997499	75167

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T123565 WP_001801861.1 NZ_CP039156:1927927-1928022 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T123565 NZ_CP039156:1927927-1928022 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT123565 NZ_CP039156:c1928107-1928050 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin