Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2448649..2449163 Replicon chromosome
Accession NZ_CP039123
Organism Streptomyces sp. SS52

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5MKQ7
Locus tag E5N77_RS11120 Protein ID WP_019326161.1
Coordinates 2448909..2449163 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7Y6HA55
Locus tag E5N77_RS11115 Protein ID WP_019326160.1
Coordinates 2448649..2448912 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5N77_RS11100 2444556..2445416 + 861 WP_019326157.1 phosphatase PAP2 family protein -
E5N77_RS11105 2445478..2448471 - 2994 WP_136235487.1 bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase -
E5N77_RS11115 2448649..2448912 + 264 WP_019326160.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
E5N77_RS11120 2448909..2449163 + 255 WP_019326161.1 Txe/YoeB family addiction module toxin Toxin
E5N77_RS11125 2449207..2449656 + 450 WP_019326162.1 VOC family protein -
E5N77_RS11130 2449678..2450346 - 669 WP_029393478.1 TetR/AcrR family transcriptional regulator -
E5N77_RS11135 2450406..2451377 + 972 WP_208949372.1 zinc-binding dehydrogenase -
E5N77_RS11140 2451404..2453167 - 1764 WP_136235488.1 NAD+ synthase -
E5N77_RS11145 2453252..2453878 - 627 WP_136235489.1 DUF305 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9827.13 Da        Isoelectric Point: 9.7377

>T123540 WP_019326161.1 NZ_CP039123:2448909-2449163 [Streptomyces sp. SS52]
VRVAFTSHGWEDYVHWAESDRKMTRRINKLIADIGRDPFKGIGKPEPLKGDLSGYWSRRIDDTHRLVYKPGDGELVVVQA
RYHY

Download         Length: 255 bp

>T123540 NZ_CP039123:2448909-2449163 [Streptomyces sp. SS52]
GTGAGAGTCGCTTTCACGTCGCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGATGACCAGACGGAT
CAACAAGCTGATCGCCGACATCGGGCGCGATCCCTTCAAGGGCATCGGCAAGCCGGAGCCGCTGAAGGGGGACCTGTCGG
GCTACTGGTCGCGGCGCATCGACGACACGCACCGTCTGGTGTACAAGCCGGGCGACGGCGAACTGGTCGTCGTCCAGGCG
CGGTACCACTACTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9774.88 Da        Isoelectric Point: 4.8784

>AT123540 WP_019326160.1 NZ_CP039123:2448649-2448912 [Streptomyces sp. SS52]
MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPKNARRLLDSIAEAEAGEARHRELI
DPDAERA

Download         Length: 264 bp

>AT123540 NZ_CP039123:2448649-2448912 [Streptomyces sp. SS52]
ATGTCCATCACCGCCAGCGAAGCCCGTCAGAACCTCTTCCCGCTGATAGAGCAGGTCAACGAGGACCACGCCCCGGTGCA
CATCACCTCCCGCAAGGGGAACGCCGTGCTGATGTCCGAGGAGGACTTCACGGCGTGGACGGAGACGGTGCACCTGCTGC
GGTCGCCGAAGAACGCCCGCCGTCTGCTCGATTCGATCGCGGAGGCCGAGGCCGGCGAGGCACGGCACCGCGAGCTGATC
GACCCGGACGCGGAGCGGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5MKQ7

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y6HA55

References