Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 143376..143912 Replicon plasmid unnamed1
Accession NZ_CP039098
Organism Piscirickettsia salmonis strain Psal-117

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1L6THY5
Locus tag Psal117_RS17075 Protein ID WP_036772441.1
Coordinates 143376..143648 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag Psal117_RS17080 Protein ID WP_032126795.1
Coordinates 143652..143912 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal117_RS17055 138568..139297 + 730 Protein_183 IS6 family transposase -
Psal117_RS17060 139340..140167 - 828 WP_048876208.1 IS30 family transposase -
Psal117_RS18620 140580..140759 + 180 WP_157894752.1 hypothetical protein -
Psal117_RS17065 140939..142003 + 1065 WP_174872554.1 IS91 family transposase -
Psal117_RS17070 142572..143300 - 729 WP_017375910.1 IS6 family transposase -
Psal117_RS17075 143376..143648 - 273 WP_036772441.1 Txe/YoeB family addiction module toxin Toxin
Psal117_RS17080 143652..143912 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Psal117_RS17085 144252..144416 + 165 Protein_190 IS6 family transposase -
Psal117_RS17090 144702..145268 + 567 Protein_191 IS6 family transposase -
Psal117_RS17095 145334..145966 - 633 Protein_192 IS6-like element ISPsa2 family transposase -
Psal117_RS17100 146036..146203 + 168 Protein_193 IS6 family transposase -
Psal117_RS17105 146254..146460 - 207 Protein_194 IS6 family transposase -
Psal117_RS17110 146544..147194 - 651 WP_155046631.1 hypothetical protein -
Psal117_RS17115 147269..148246 + 978 WP_036771347.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..168649 168649
- inside IScluster/Tn - - 132954..165420 32466


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10785.31 Da        Isoelectric Point: 7.8926

>T123519 WP_036772441.1 NZ_CP039098:c143648-143376 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRMPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
ISACRYHYDQ

Download         Length: 273 bp

>T123519 NZ_CP039098:c143648-143376 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
GCTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCATGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTTCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT123519 WP_032126795.1 NZ_CP039098:c143912-143652 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT123519 NZ_CP039098:c143912-143652 [Piscirickettsia salmonis]
ATGCTACGAGATAACATCAATGCTACGGCAGCACGGGATAATTTTAAGAGTACCTGTGATACAGTGTGTGAAAACAATGC
TCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGTATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6THY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References