Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 51433..51969 Replicon plasmid unnamed2
Accession NZ_CP039089
Organism Piscirickettsia salmonis strain Psal-111

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag Psal111_RS17670 Protein ID WP_016211910.1
Coordinates 51433..51705 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag Psal111_RS17675 Protein ID WP_032126795.1
Coordinates 51709..51969 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal111_RS17635 47362..47619 - 258 WP_098082828.1 transposase -
Psal111_RS17640 47852..48769 + 918 Protein_52 IS30 family transposase -
Psal111_RS17645 48886..49350 + 465 WP_036774631.1 hypothetical protein -
Psal111_RS17650 49409..49549 - 141 Protein_54 helix-turn-helix domain-containing protein -
Psal111_RS17655 49713..49859 + 147 WP_157894761.1 transposase zinc-binding domain-containing protein -
Psal111_RS17660 50576..50716 - 141 Protein_56 helix-turn-helix domain-containing protein -
Psal111_RS17665 50889..51107 + 219 WP_155046644.1 hypothetical protein -
Psal111_RS17670 51433..51705 - 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
Psal111_RS17675 51709..51969 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Psal111_RS17680 52242..52832 + 591 WP_027242600.1 site-specific integrase -
Psal111_RS17685 52860..54263 - 1404 WP_048876031.1 IS4 family transposase -
Psal111_RS17690 54967..55926 - 960 Protein_62 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..58537 58537
- flank IS/Tn - - 55295..55489 194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T123508 WP_016211910.1 NZ_CP039089:c51705-51433 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T123508 NZ_CP039089:c51705-51433 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
ACTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCACGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTGCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT123508 WP_032126795.1 NZ_CP039089:c51969-51709 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT123508 NZ_CP039089:c51969-51709 [Piscirickettsia salmonis]
ATGTTACGAGACAACATTAATGCTACGGCAGCGCGGGATAATTTTAAGAGTACCTGTGATACGGTGTGTGAAAACAATGC
CCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGCATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References