Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 30066..30602 Replicon plasmid unnamed1
Accession NZ_CP039082
Organism Piscirickettsia salmonis strain Psal-110

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1L6THY5
Locus tag Psal110_RS16335 Protein ID WP_036772441.1
Coordinates 30330..30602 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag Psal110_RS16330 Protein ID WP_032126795.1
Coordinates 30066..30326 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal110_RS16290 25882..26571 + 690 WP_017375909.1 hypothetical protein -
Psal110_RS16295 26697..27434 + 738 WP_157894753.1 hypothetical protein -
Psal110_RS16300 27518..27724 + 207 Protein_35 IS6 family transposase -
Psal110_RS16305 27775..27942 - 168 Protein_36 IS6 family transposase -
Psal110_RS16310 28012..28644 + 633 Protein_37 IS6-like element ISPsa2 family transposase -
Psal110_RS16315 28710..29276 - 567 Protein_38 IS6 family transposase -
Psal110_RS16325 29562..29726 - 165 Protein_39 IS6 family transposase -
Psal110_RS16330 30066..30326 + 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Psal110_RS16335 30330..30602 + 273 WP_036772441.1 Txe/YoeB family addiction module toxin Toxin
Psal110_RS16340 30678..31406 + 729 WP_017375910.1 IS6 family transposase -
Psal110_RS16345 31976..33040 - 1065 WP_174872554.1 IS91 family transposase -
Psal110_RS18695 33220..33399 - 180 WP_157894752.1 hypothetical protein -
Psal110_RS16355 33812..34639 + 828 WP_048876208.1 IS30 family transposase -
Psal110_RS16360 34682..35411 - 730 Protein_46 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..177162 177162
- inside IScluster/Tn - - 24019..41025 17006


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10785.31 Da        Isoelectric Point: 7.8926

>T123499 WP_036772441.1 NZ_CP039082:30330-30602 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRMPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
ISACRYHYDQ

Download         Length: 273 bp

>T123499 NZ_CP039082:30330-30602 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
GCTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCATGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTTCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT123499 WP_032126795.1 NZ_CP039082:30066-30326 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT123499 NZ_CP039082:30066-30326 [Piscirickettsia salmonis]
ATGCTACGAGATAACATCAATGCTACGGCAGCACGGGATAATTTTAAGAGTACCTGTGATACAGTGTGTGAAAACAATGC
TCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGTATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6THY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References