Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 38294..38830 Replicon plasmid unnamed1
Accession NZ_CP039051
Organism Piscirickettsia salmonis strain Psal-081

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1L6THY5
Locus tag Psal081_RS16300 Protein ID WP_036772441.1
Coordinates 38558..38830 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag Psal081_RS16295 Protein ID WP_032126795.1
Coordinates 38294..38554 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal081_RS16255 34110..34799 + 690 WP_017375909.1 hypothetical protein -
Psal081_RS16260 34847..35662 + 816 WP_036775032.1 hypothetical protein -
Psal081_RS16265 35746..35952 + 207 Protein_48 IS6 family transposase -
Psal081_RS16270 36003..36170 - 168 Protein_49 IS6 family transposase -
Psal081_RS16275 36240..36872 + 633 Protein_50 IS6-like element ISPsa2 family transposase -
Psal081_RS16280 36938..37504 - 567 Protein_51 IS6 family transposase -
Psal081_RS16290 37790..37954 - 165 Protein_52 IS6 family transposase -
Psal081_RS16295 38294..38554 + 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Psal081_RS16300 38558..38830 + 273 WP_036772441.1 Txe/YoeB family addiction module toxin Toxin
Psal081_RS16305 38906..39634 + 729 WP_017375910.1 IS6 family transposase -
Psal081_RS16310 40204..41268 - 1065 WP_174872554.1 IS91 family transposase -
Psal081_RS18580 41448..41627 - 180 WP_157894752.1 hypothetical protein -
Psal081_RS16315 42040..42867 + 828 WP_048876208.1 IS30 family transposase -
Psal081_RS16320 42910..43639 - 730 Protein_59 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..179546 179546
- inside IScluster/Tn - - 32247..49253 17006


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10785.31 Da        Isoelectric Point: 7.8926

>T123465 WP_036772441.1 NZ_CP039051:38558-38830 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRMPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
ISACRYHYDQ

Download         Length: 273 bp

>T123465 NZ_CP039051:38558-38830 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
GCTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCATGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTTCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT123465 WP_032126795.1 NZ_CP039051:38294-38554 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT123465 NZ_CP039051:38294-38554 [Piscirickettsia salmonis]
ATGCTACGAGATAACATCAATGCTACGGCAGCACGGGATAATTTTAAGAGTACCTGTGATACAGTGTGTGAAAACAATGC
TCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGTATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6THY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References