Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 72929..73465 Replicon plasmid unnamed1
Accession NZ_CP038958
Organism Piscirickettsia salmonis strain Psal-041

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag Psal041_RS16700 Protein ID WP_016211910.1
Coordinates 72929..73201 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag Psal041_RS16705 Protein ID WP_032126795.1
Coordinates 73205..73465 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal041_RS16675 68116..68490 - 375 WP_016212499.1 hypothetical protein -
Psal041_RS16680 68827..69429 - 603 Protein_91 IS30 family transposase -
Psal041_RS16685 69489..70642 + 1154 WP_129556499.1 IS3 family transposase -
Psal041_RS16690 70651..71049 - 399 WP_075273786.1 helix-turn-helix domain-containing protein -
Psal041_RS16695 71482..72603 + 1122 WP_016211913.1 hypothetical protein -
Psal041_RS16700 72929..73201 - 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
Psal041_RS16705 73205..73465 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Psal041_RS16710 73738..74328 + 591 WP_016211912.1 site-specific integrase -
Psal041_RS16715 74418..75119 + 702 WP_129556698.1 IS6 family transposase -
Psal041_RS16720 75233..75598 + 366 WP_054300249.1 IS630 transposase-related protein -
Psal041_RS16725 75613..76119 + 507 WP_129556449.1 IS630 family transposase -
Psal041_RS16735 77355..77831 - 477 WP_051307374.1 Clp protease ClpP -
Psal041_RS16740 78072..78398 + 327 WP_016212298.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..149109 149109
- flank IS/Tn - - 74418..75119 701


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T123399 WP_016211910.1 NZ_CP038958:c73201-72929 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T123399 NZ_CP038958:c73201-72929 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
ACTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCACGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTGCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT123399 WP_032126795.1 NZ_CP038958:c73465-73205 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT123399 NZ_CP038958:c73465-73205 [Piscirickettsia salmonis]
ATGTTACGAGACAACATTAATGCTACGGCAGCGCGGGATAATTTTAAGAGTACCTGTGATACGGTGTGTGAAAACAATGC
CCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGCATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References