Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 118719..119255 Replicon plasmid unnamed1
Accession NZ_CP038953
Organism Piscirickettsia salmonis strain Psal-040

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag Psal040_RS17000 Protein ID WP_016211910.1
Coordinates 118719..118991 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag Psal040_RS17005 Protein ID WP_032126795.1
Coordinates 118995..119255 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal040_RS16975 113906..114280 - 375 WP_016212499.1 hypothetical protein -
Psal040_RS16980 114617..115219 - 603 Protein_142 IS30 family transposase -
Psal040_RS16985 115279..116432 + 1154 WP_129556499.1 IS3 family transposase -
Psal040_RS16990 116441..116839 - 399 WP_075273786.1 helix-turn-helix domain-containing protein -
Psal040_RS16995 117272..118393 + 1122 WP_016211913.1 hypothetical protein -
Psal040_RS17000 118719..118991 - 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
Psal040_RS17005 118995..119255 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Psal040_RS17010 119528..120118 + 591 WP_016211912.1 site-specific integrase -
Psal040_RS17015 120208..120909 + 702 WP_129556698.1 IS6 family transposase -
Psal040_RS17020 121023..121388 + 366 WP_054300249.1 IS630 transposase-related protein -
Psal040_RS17025 121403..121909 + 507 WP_129556449.1 IS630 family transposase -
Psal040_RS17035 123145..123621 - 477 WP_051307374.1 Clp protease ClpP -
Psal040_RS17040 123862..124188 + 327 WP_016212298.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..194899 194899
- flank IS/Tn - - 120208..120909 701


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T123395 WP_016211910.1 NZ_CP038953:c118991-118719 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T123395 NZ_CP038953:c118991-118719 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
ACTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCACGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTGCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT123395 WP_032126795.1 NZ_CP038953:c119255-118995 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT123395 NZ_CP038953:c119255-118995 [Piscirickettsia salmonis]
ATGTTACGAGACAACATTAATGCTACGGCAGCGCGGGATAATTTTAAGAGTACCTGTGATACGGTGTGTGAAAACAATGC
CCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGCATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References