Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 156740..157276 Replicon plasmid unnamed1
Accession NZ_CP038933
Organism Piscirickettsia salmonis strain Psal-025

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag Psal025_RS17395 Protein ID WP_016211910.1
Coordinates 157004..157276 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag Psal025_RS17390 Protein ID WP_032126795.1
Coordinates 156740..157000 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal025_RS17355 152478..152804 - 327 WP_016212298.1 hypothetical protein -
Psal025_RS17360 153045..153521 + 477 WP_051307374.1 Clp protease ClpP -
Psal025_RS17365 153636..153929 + 294 WP_075275158.1 transposase -
Psal025_RS17370 153890..154570 + 681 Protein_197 IS3 family transposase -
Psal025_RS17375 154775..155077 + 303 WP_098082791.1 IS3 family transposase -
Psal025_RS17380 155086..155787 - 702 WP_129556698.1 IS6 family transposase -
Psal025_RS17385 155877..156467 - 591 WP_016211912.1 site-specific integrase -
Psal025_RS17390 156740..157000 + 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Psal025_RS17395 157004..157276 + 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
Psal025_RS17400 157602..158723 - 1122 WP_016211913.1 hypothetical protein -
Psal025_RS17405 159156..159554 + 399 WP_075273786.1 helix-turn-helix domain-containing protein -
Psal025_RS17410 159563..160120 - 558 WP_081377915.1 IS3 family transposase -
Psal025_RS17415 160265..160594 - 330 WP_081377914.1 IS3 family transposase -
Psal025_RS17420 160711..161004 - 294 WP_032126637.1 transposase -
Psal025_RS17425 161064..161666 + 603 Protein_208 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..225323 225323


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T123381 WP_016211910.1 NZ_CP038933:157004-157276 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T123381 NZ_CP038933:157004-157276 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
ACTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCACGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTGCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT123381 WP_032126795.1 NZ_CP038933:156740-157000 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT123381 NZ_CP038933:156740-157000 [Piscirickettsia salmonis]
ATGTTACGAGACAACATTAATGCTACGGCAGCGCGGGATAATTTTAAGAGTACCTGTGATACGGTGTGTGAAAACAATGC
CCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGCATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References