Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 78684..79220 Replicon plasmid unnamed1
Accession NZ_CP038933
Organism Piscirickettsia salmonis strain Psal-025

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag Psal025_RS16835 Protein ID WP_016211910.1
Coordinates 78684..78956 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag Psal025_RS16840 Protein ID WP_032126795.1
Coordinates 78960..79220 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal025_RS16800 74613..74870 - 258 WP_098082828.1 transposase -
Psal025_RS16805 75103..76020 + 918 Protein_86 IS30 family transposase -
Psal025_RS16810 76137..76601 + 465 WP_036774631.1 hypothetical protein -
Psal025_RS16815 76660..76800 - 141 Protein_88 helix-turn-helix domain-containing protein -
Psal025_RS16820 76964..77110 + 147 WP_157894761.1 transposase zinc-binding domain-containing protein -
Psal025_RS16825 77827..77967 - 141 Protein_90 helix-turn-helix domain-containing protein -
Psal025_RS16830 78086..78358 + 273 WP_027242602.1 hypothetical protein -
Psal025_RS16835 78684..78956 - 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
Psal025_RS16840 78960..79220 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Psal025_RS16845 79493..80083 + 591 WP_027242600.1 site-specific integrase -
Psal025_RS16850 80111..81514 - 1404 WP_048876031.1 IS4 family transposase -
Psal025_RS16855 82218..83177 - 960 Protein_96 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..225323 225323
- flank IS/Tn - - 82546..82932 386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T123379 WP_016211910.1 NZ_CP038933:c78956-78684 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T123379 NZ_CP038933:c78956-78684 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
ACTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCACGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTGCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT123379 WP_032126795.1 NZ_CP038933:c79220-78960 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT123379 NZ_CP038933:c79220-78960 [Piscirickettsia salmonis]
ATGTTACGAGACAACATTAATGCTACGGCAGCGCGGGATAATTTTAAGAGTACCTGTGATACGGTGTGTGAAAACAATGC
CCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGCATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References