Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 68070..68606 Replicon plasmid unnamed1
Accession NZ_CP038928
Organism Piscirickettsia salmonis strain Psal-013

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1L6THY5
Locus tag Psal013_RS16810 Protein ID WP_036772441.1
Coordinates 68070..68342 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag Psal013_RS16815 Protein ID WP_032126795.1
Coordinates 68346..68606 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal013_RS18670 63292..63459 + 168 WP_169834792.1 hypothetical protein -
Psal013_RS16785 63671..64447 - 777 WP_017375850.1 N-acetylmuramoyl-L-alanine amidase -
Psal013_RS16790 64808..65536 + 729 WP_036771279.1 IS6 family transposase -
Psal013_RS16795 65606..65806 + 201 WP_155046634.1 transposase zinc-binding domain-containing protein -
Psal013_RS16800 65725..66696 + 972 WP_048876229.1 IS91 family transposase -
Psal013_RS16805 67266..67994 - 729 WP_017375910.1 IS6 family transposase -
Psal013_RS16810 68070..68342 - 273 WP_036772441.1 Txe/YoeB family addiction module toxin Toxin
Psal013_RS16815 68346..68606 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Psal013_RS16820 68946..69110 + 165 Protein_92 IS6 family transposase -
Psal013_RS16825 69396..69962 + 567 Protein_93 IS6 family transposase -
Psal013_RS16830 69965..70396 - 432 Protein_94 IS6 family transposase -
Psal013_RS16835 70785..71048 - 264 Protein_95 IS6 family transposase -
Psal013_RS16840 71128..72255 - 1128 WP_036772450.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..159159 159159
- inside IScluster/Tn - - 59193..87947 28754


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10785.31 Da        Isoelectric Point: 7.8926

>T123377 WP_036772441.1 NZ_CP038928:c68342-68070 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRMPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
ISACRYHYDQ

Download         Length: 273 bp

>T123377 NZ_CP038928:c68342-68070 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
GCTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCATGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTTCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT123377 WP_032126795.1 NZ_CP038928:c68606-68346 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT123377 NZ_CP038928:c68606-68346 [Piscirickettsia salmonis]
ATGCTACGAGATAACATCAATGCTACGGCAGCACGGGATAATTTTAAGAGTACCTGTGATACAGTGTGTGAAAACAATGC
TCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGTATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6THY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References