Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 50327..50863 Replicon plasmid unnamed2
Accession NZ_CP038920
Organism Piscirickettsia salmonis strain Psal-010b

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag Psal010b_RS17630 Protein ID WP_016211910.1
Coordinates 50327..50599 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag Psal010b_RS17635 Protein ID WP_032126795.1
Coordinates 50603..50863 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal010b_RS17595 46256..46513 - 258 WP_098082828.1 transposase -
Psal010b_RS17600 46746..47663 + 918 Protein_50 IS30 family transposase -
Psal010b_RS17605 47780..48244 + 465 WP_036774631.1 hypothetical protein -
Psal010b_RS17610 48303..48443 - 141 Protein_52 helix-turn-helix domain-containing protein -
Psal010b_RS17615 48607..48753 + 147 WP_157894761.1 transposase zinc-binding domain-containing protein -
Psal010b_RS17620 49470..49610 - 141 Protein_54 helix-turn-helix domain-containing protein -
Psal010b_RS17625 49783..50001 + 219 WP_155046644.1 hypothetical protein -
Psal010b_RS17630 50327..50599 - 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
Psal010b_RS17635 50603..50863 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Psal010b_RS17640 51136..51726 + 591 WP_027242600.1 site-specific integrase -
Psal010b_RS17645 51754..53157 - 1404 WP_048876031.1 IS4 family transposase -
Psal010b_RS17650 53861..54820 - 960 Protein_60 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..57431 57431
- flank IS/Tn - - 54189..54383 194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T123368 WP_016211910.1 NZ_CP038920:c50599-50327 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T123368 NZ_CP038920:c50599-50327 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
ACTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCACGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTGCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT123368 WP_032126795.1 NZ_CP038920:c50863-50603 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT123368 NZ_CP038920:c50863-50603 [Piscirickettsia salmonis]
ATGTTACGAGACAACATTAATGCTACGGCAGCGCGGGATAATTTTAAGAGTACCTGTGATACGGTGTGTGAAAACAATGC
CCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGCATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References