Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 54166..54702 Replicon plasmid unnamed1
Accession NZ_CP038914
Organism Piscirickettsia salmonis strain Psal-010a

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag Psal010a_RS16760 Protein ID WP_016211910.1
Coordinates 54166..54438 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag Psal010a_RS16765 Protein ID WP_032126795.1
Coordinates 54442..54702 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal010a_RS16730 49776..50378 - 603 Protein_71 IS30 family transposase -
Psal010a_RS16735 50438..50731 + 294 WP_032126637.1 transposase -
Psal010a_RS16740 50848..51177 + 330 WP_081377914.1 IS3 family transposase -
Psal010a_RS16745 51322..51879 + 558 WP_081377915.1 IS3 family transposase -
Psal010a_RS16750 51888..52286 - 399 WP_075273786.1 helix-turn-helix domain-containing protein -
Psal010a_RS16755 52719..53840 + 1122 WP_016211913.1 hypothetical protein -
Psal010a_RS16760 54166..54438 - 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
Psal010a_RS16765 54442..54702 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Psal010a_RS16770 54975..55565 + 591 WP_016211912.1 site-specific integrase -
Psal010a_RS16775 55655..56356 + 702 WP_129556698.1 IS6 family transposase -
Psal010a_RS16780 56365..56667 - 303 WP_098082791.1 IS3 family transposase -
Psal010a_RS16785 56872..57552 - 681 Protein_82 IS3 family transposase -
Psal010a_RS16790 57513..57806 - 294 WP_075275158.1 transposase -
Psal010a_RS16795 57921..58397 - 477 WP_051307374.1 Clp protease ClpP -
Psal010a_RS16800 58638..58964 + 327 WP_016212298.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..108847 108847


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T123361 WP_016211910.1 NZ_CP038914:c54438-54166 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T123361 NZ_CP038914:c54438-54166 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
ACTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCACGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTGCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT123361 WP_032126795.1 NZ_CP038914:c54702-54442 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT123361 NZ_CP038914:c54702-54442 [Piscirickettsia salmonis]
ATGTTACGAGACAACATTAATGCTACGGCAGCGCGGGATAATTTTAAGAGTACCTGTGATACGGTGTGTGAAAACAATGC
CCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGCATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References