Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 478297..478833 Replicon chromosome
Accession NZ_CP038908
Organism Piscirickettsia salmonis strain Psal-009

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag Psal009_RS02625 Protein ID WP_016211910.1
Coordinates 478297..478569 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag Psal009_RS02630 Protein ID WP_032126795.1
Coordinates 478573..478833 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal009_RS02600 473484..473858 - 375 WP_016212499.1 hypothetical protein -
Psal009_RS02605 474195..474797 - 603 Protein_504 IS30 family transposase -
Psal009_RS02610 474857..476010 + 1154 WP_129556499.1 IS3 family transposase -
Psal009_RS02615 476019..476417 - 399 WP_075273786.1 helix-turn-helix domain-containing protein -
Psal009_RS02620 476850..477971 + 1122 WP_016211913.1 hypothetical protein -
Psal009_RS02625 478297..478569 - 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
Psal009_RS02630 478573..478833 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Psal009_RS02635 479106..479696 + 591 WP_016211912.1 site-specific integrase -
Psal009_RS02640 479786..480487 + 702 WP_129556698.1 IS6 family transposase -
Psal009_RS02645 480601..480966 + 366 WP_054300249.1 IS630 transposase-related protein -
Psal009_RS02650 480981..481487 + 507 WP_129556449.1 IS630 family transposase -
Psal009_RS02660 482723..483199 - 477 WP_051307374.1 Clp protease ClpP -
Psal009_RS02665 483440..483766 + 327 WP_016212298.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 313707..514002 200295
- flank IS/Tn - - 479786..480487 701


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T123357 WP_016211910.1 NZ_CP038908:c478569-478297 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T123357 NZ_CP038908:c478569-478297 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
ACTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCACGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTGCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT123357 WP_032126795.1 NZ_CP038908:c478833-478573 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT123357 NZ_CP038908:c478833-478573 [Piscirickettsia salmonis]
ATGTTACGAGACAACATTAATGCTACGGCAGCGCGGGATAATTTTAAGAGTACCTGTGATACGGTGTGTGAAAACAATGC
CCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGCATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References