Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 66318..66854 Replicon plasmid unnamed1
Accession NZ_CP038905
Organism Piscirickettsia salmonis strain Psal-008

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1L6THY5
Locus tag Psal008_RS16630 Protein ID WP_036772441.1
Coordinates 66318..66590 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag Psal008_RS16635 Protein ID WP_032126795.1
Coordinates 66594..66854 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal008_RS16605 61509..62238 + 730 Protein_81 IS6 family transposase -
Psal008_RS16610 62281..63108 - 828 WP_048876208.1 IS30 family transposase -
Psal008_RS18410 63521..63700 + 180 WP_157894752.1 hypothetical protein -
Psal008_RS16620 63880..64944 + 1065 WP_174872554.1 IS91 family transposase -
Psal008_RS16625 65514..66242 - 729 WP_017375910.1 IS6 family transposase -
Psal008_RS16630 66318..66590 - 273 WP_036772441.1 Txe/YoeB family addiction module toxin Toxin
Psal008_RS16635 66594..66854 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Psal008_RS16640 67194..67358 + 165 Protein_88 IS6 family transposase -
Psal008_RS16645 67644..68210 + 567 Protein_89 IS6 family transposase -
Psal008_RS16650 68213..68644 - 432 Protein_90 IS6 family transposase -
Psal008_RS16655 69033..69296 - 264 Protein_91 IS6 family transposase -
Psal008_RS16660 69376..70503 - 1128 WP_036772450.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..165781 165781
- inside IScluster/Tn - - 55895..86483 30588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10785.31 Da        Isoelectric Point: 7.8926

>T123354 WP_036772441.1 NZ_CP038905:c66590-66318 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRMPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
ISACRYHYDQ

Download         Length: 273 bp

>T123354 NZ_CP038905:c66590-66318 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
GCTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCATGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTTCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT123354 WP_032126795.1 NZ_CP038905:c66854-66594 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT123354 NZ_CP038905:c66854-66594 [Piscirickettsia salmonis]
ATGCTACGAGATAACATCAATGCTACGGCAGCACGGGATAATTTTAAGAGTACCTGTGATACAGTGTGTGAAAACAATGC
TCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGTATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6THY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References