Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 31034..31570 Replicon plasmid unnamed1
Accession NZ_CP038899
Organism Piscirickettsia salmonis strain Psal-006b

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1L6THY5
Locus tag Psal006b_RS16415 Protein ID WP_036772441.1
Coordinates 31298..31570 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag Psal006b_RS16410 Protein ID WP_032126795.1
Coordinates 31034..31294 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal006b_RS16365 26412..26882 - 471 WP_155062845.1 transposase -
Psal006b_RS16370 27027..27677 - 651 WP_155062847.1 IS5 family transposase -
Psal006b_RS16375 27752..28402 + 651 WP_155046631.1 hypothetical protein -
Psal006b_RS16380 28486..28692 + 207 Protein_38 IS6 family transposase -
Psal006b_RS16385 28743..28910 - 168 Protein_39 IS6 family transposase -
Psal006b_RS16390 28980..29612 + 633 Protein_40 IS6-like element ISPsa2 family transposase -
Psal006b_RS16395 29678..30244 - 567 Protein_41 IS6 family transposase -
Psal006b_RS16405 30530..30694 - 165 Protein_42 IS6 family transposase -
Psal006b_RS16410 31034..31294 + 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Psal006b_RS16415 31298..31570 + 273 WP_036772441.1 Txe/YoeB family addiction module toxin Toxin
Psal006b_RS16420 31646..32374 + 729 WP_017375910.1 IS6 family transposase -
Psal006b_RS16425 32944..34008 - 1065 WP_174872554.1 IS91 family transposase -
Psal006b_RS19180 34188..34367 - 180 WP_157894752.1 hypothetical protein -
Psal006b_RS16435 34780..35607 + 828 WP_048876208.1 IS30 family transposase -
Psal006b_RS16440 35650..36379 - 730 Protein_49 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..186370 186370
- inside IScluster/Tn - - 10357..41993 31636


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10785.31 Da        Isoelectric Point: 7.8926

>T123346 WP_036772441.1 NZ_CP038899:31298-31570 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRMPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
ISACRYHYDQ

Download         Length: 273 bp

>T123346 NZ_CP038899:31298-31570 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
GCTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCATGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTTCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT123346 WP_032126795.1 NZ_CP038899:31034-31294 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT123346 NZ_CP038899:31034-31294 [Piscirickettsia salmonis]
ATGCTACGAGATAACATCAATGCTACGGCAGCACGGGATAATTTTAAGAGTACCTGTGATACAGTGTGTGAAAACAATGC
TCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGTATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6THY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References