Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1052453..1053255 Replicon chromosome
Accession NZ_CP038874
Organism Pasteurella multocida strain FCf76

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E5136_RS05085 Protein ID WP_061406326.1
Coordinates 1052929..1053255 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E5136_RS05080 Protein ID WP_005757699.1
Coordinates 1052453..1052779 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5136_RS05060 1047889..1048920 + 1032 WP_061406329.1 hypothetical protein -
E5136_RS05065 1049156..1050166 + 1011 WP_061406328.1 hypothetical protein -
E5136_RS05070 1050229..1050819 + 591 WP_061406438.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
E5136_RS05075 1050878..1052398 + 1521 WP_061406327.1 DUF560 domain-containing protein -
E5136_RS05080 1052453..1052779 - 327 WP_005757699.1 HigA family addiction module antidote protein Antitoxin
E5136_RS05085 1052929..1053255 - 327 WP_061406326.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E5136_RS05090 1053413..1053889 + 477 WP_042742721.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
E5136_RS05095 1053963..1054832 - 870 WP_061406325.1 VirK/YbjX family protein -
E5136_RS05100 1054943..1055560 + 618 WP_005724253.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
E5136_RS05105 1055669..1057198 + 1530 WP_061406324.1 YifB family Mg chelatase-like AAA ATPase -
E5136_RS05110 1057252..1057938 - 687 WP_061406323.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12923.75 Da        Isoelectric Point: 9.6705

>T123324 WP_061406326.1 NZ_CP038874:c1053255-1052929 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSQPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

>T123324 NZ_CP038874:c1053255-1052929 [Pasteurella multocida]
ATGGACAGAGTCCGATTTAATCTTACGGAAGATAGCTTCCAAGACAAGTATCTGTATGAGTATTTTTTATATGGAAGTAA
GCATAAAAATATTCCAAGTGATATAGAAAATACGCTAGCGCATAAATTAGATATGTTAGATAGCGCAAATACTTTGAGCG
ATTTGCGAAGTCAACCAGGTAATAAATTGGAAAAATTGGAGCCTAAAACGAGTGGGCTATATTCTATCAGAGTGAATGTG
AAATATCGTTTAATATTTAAATATAAAGAAAGTAATTTTCCAAAAATAACAGAGTTGAGATTAGATAAACATCAATATAG
ATTATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT123324 WP_005757699.1 NZ_CP038874:c1052779-1052453 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp

>AT123324 NZ_CP038874:c1052779-1052453 [Pasteurella multocida]
ATGAGTAGAGTACAAAGAAAGCCATCAACAGTGGGTGATATTTTATTAGATGAATATTTAGTTCCACTAAATTTGAAAAT
TGCAGATTTAGCTACAATGTTAGATGTTCATCGTAATACAGCGAGTGCACTCGTTAATAATAATACTAAATTGTCTTTAG
AAATGGCACTGAAACTAGCAAAACTATTTAATACAAGTCCTGAGTTTTGGTTAAATTTACAAATGAAATTAGACTTATGG
GAAATTGAAAACAATGCTAGGTTTCAAGAAAGTTTAAAGAAAATTTCGTCTATTGATCAGCATAATCTGTTAGAAAAAAT
CGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References