Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1609135..1609874 Replicon chromosome
Accession NZ_CP038873
Organism Pasteurella multocida strain FCf45

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E5135_RS07450 Protein ID WP_061406326.1
Coordinates 1609135..1609461 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E5135_RS07455 Protein ID WP_005757699.1
Coordinates 1609548..1609874 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5135_RS07425 1604452..1605138 + 687 WP_061406323.1 hypothetical protein -
E5135_RS07430 1605192..1606721 - 1530 WP_061406324.1 YifB family Mg chelatase-like AAA ATPase -
E5135_RS07435 1606830..1607447 - 618 WP_005724253.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
E5135_RS07440 1607558..1608427 + 870 WP_061406325.1 VirK/YbjX family protein -
E5135_RS07445 1608501..1608977 - 477 WP_042742721.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
E5135_RS07450 1609135..1609461 + 327 WP_061406326.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E5135_RS07455 1609548..1609874 + 327 WP_005757699.1 HigA family addiction module antidote protein Antitoxin
E5135_RS07460 1609929..1611449 - 1521 WP_061406327.1 DUF560 domain-containing protein -
E5135_RS07465 1611508..1612098 - 591 WP_061406438.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
E5135_RS07470 1612161..1613171 - 1011 WP_061406328.1 hypothetical protein -
E5135_RS07475 1613407..1614438 - 1032 WP_061406329.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12923.75 Da        Isoelectric Point: 9.6705

>T123323 WP_061406326.1 NZ_CP038873:1609135-1609461 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSQPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

>T123323 NZ_CP038873:1609135-1609461 [Pasteurella multocida]
ATGGACAGAGTCCGATTTAATCTTACGGAAGATAGCTTCCAAGACAAGTATCTGTATGAGTATTTTTTATATGGAAGTAA
GCATAAAAATATTCCAAGTGATATAGAAAATACGCTAGCGCATAAATTAGATATGTTAGATAGCGCAAATACTTTGAGCG
ATTTGCGAAGTCAACCAGGTAATAAATTGGAAAAATTGGAGCCTAAAACGAGTGGGCTATATTCTATCAGAGTGAATGTG
AAATATCGTTTAATATTTAAATATAAAGAAAGTAATTTTCCAAAAATAACAGAGTTGAGATTAGATAAACATCAATATAG
ATTATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT123323 WP_005757699.1 NZ_CP038873:1609548-1609874 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp

>AT123323 NZ_CP038873:1609548-1609874 [Pasteurella multocida]
ATGAGTAGAGTACAAAGAAAGCCATCAACAGTGGGTGATATTTTATTAGATGAATATTTAGTTCCACTAAATTTGAAAAT
TGCAGATTTAGCTACAATGTTAGATGTTCATCGTAATACAGCGAGTGCACTCGTTAATAATAATACTAAATTGTCTTTAG
AAATGGCACTGAAACTAGCAAAACTATTTAATACAAGTCCTGAGTTTTGGTTAAATTTACAAATGAAATTAGACTTATGG
GAAATTGAAAACAATGCTAGGTTTCAAGAAAGTTTAAAGAAAATTTCGTCTATTGATCAGCATAATCTGTTAGAAAAAAT
CGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References