Detailed information of TA system TA123286

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1441748..1442119
• Replicon: chromosome
• Accession: NZ_CP038859
• Organism: Escherichia coli strain 357900

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A7W3G0W6
• Locus tag: A7A13_RS06895
• Protein ID: WP_072130784.1
• Coordinates: 1441925..1442119 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1441748..1441926 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7A13_RS06865	1437500..1437673	+	174	WP_001296046.1	hypothetical protein	-
A7A13_RS06870	1437703..1439076	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
A7A13_RS06875	1439205..1440140	-	936	WP_001157377.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
A7A13_RS06880	1440192..1441427	-	1236	WP_072001411.1	site-specific integrase	-
A7A13_RS06885	1441429..1441644	-	216	WP_000079604.1	excisionase XisR	-
A7A13_RS06890	1441744..1441932	-	189	WP_001302840.1	DUF1187 family protein	-
-	1441748..1441926	+	179	NuclAT_0	-	Antitoxin
-	1441748..1441926	+	179	NuclAT_0	-	Antitoxin
-	1441748..1441926	+	179	NuclAT_0	-	Antitoxin
-	1441748..1441926	+	179	NuclAT_0	-	Antitoxin
A7A13_RS06895	1441925..1442119	-	195	WP_072130784.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
A7A13_RS06900	1442176..1443009	-	834	WP_000166322.1	recombination protein RecT	-
A7A13_RS06905	1443002..1445653	-	2652	WP_176670681.1	exodeoxyribonuclease VIII	-
A7A13_RS06910	1445755..1446030	-	276	WP_032218014.1	hypothetical protein	-
A7A13_RS06915	1446105..1446281	-	177	WP_032218016.1	hypothetical protein	-
A7A13_RS06920	1446275..1446496	-	222	WP_000560226.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1440192..1486395	46203

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7135.00 Da
• Isoelectric Point: 8.0115

>T123286 WP_072130784.1 NZ_CP038859:c1442119-1441925 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKDISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTENINGGVHV

Nucleotide

• Length: 195 bp

>T123286 NZ_CP038859:c1442119-1441925 [Escherichia coli]
TTGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTGAAAGACATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCGCTCGAAAGATGGAATAAACGAA
CCACTGAAAATATTAATGGAGGCGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT123286 NZ_CP038859:1441748-1441926 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7W3G0W6

Antitoxin