Detailed information of TA system TA123237

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 27190..27692
• Replicon: plasmid pVag2
• Accession: NZ_CP038855
• Organism: Pantoea vagans strain LMG 24199

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: EGO56_RS21620
• Protein ID: WP_135911073.1
• Coordinates: 27190..27444 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: EGO56_RS21625
• Protein ID: WP_135911074.1
• Coordinates: 27441..27692 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGO56_RS21605	23668..23967	+	300	WP_135911070.1	type II toxin-antitoxin system HigB family toxin	-
EGO56_RS21610	23967..24359	+	393	WP_135911071.1	transcriptional regulator	-
EGO56_RS21615	24579..27116	+	2538	WP_135911072.1	excinuclease ABC subunit UvrA	-
EGO56_RS21620	27190..27444	-	255	WP_135911073.1	Txe/YoeB family addiction module toxin	Toxin
EGO56_RS21625	27441..27692	-	252	WP_135911074.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
EGO56_RS21630	27852..28691	-	840	WP_135911075.1	MBL fold metallo-hydrolase	-
EGO56_RS21635	28856..30169	-	1314	WP_033785223.1	CitMHS family transporter	-
EGO56_RS21640	30511..31962	-	1452	WP_135911076.1	flagellin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..180464	180464

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9997.42 Da
• Isoelectric Point: 9.3796

>T123237 WP_135911073.1 NZ_CP038855:c27444-27190 [Pantoea vagans]
VKLTWSEEAWEDYLYWQDTDKKTVKKINALLKEASRTPFEGKGKPEPLKHNLARFWSRRITAEHRLVYAVSEDALLIASC
RYHY

Nucleotide

• Length: 255 bp

>T123237 NZ_CP038855:c27444-27190 [Pantoea vagans]
GTGAAGCTGACCTGGTCCGAAGAAGCCTGGGAAGATTATCTCTACTGGCAGGATACCGATAAAAAAACGGTCAAAAAGAT
TAATGCGTTGCTAAAAGAGGCCAGCAGGACGCCCTTTGAAGGCAAGGGAAAACCCGAGCCATTAAAGCATAATCTTGCAA
GATTCTGGTCACGCAGAATTACGGCAGAACATCGGCTGGTTTATGCAGTCAGTGAAGACGCTTTATTAATCGCCTCATGC
CGCTATCATTATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9353.51 Da
• Isoelectric Point: 4.4297

>AT123237 WP_135911074.1 NZ_CP038855:c27692-27441 [Pantoea vagans]
MRAISYSEARQNLSATMVQTVEDKAPVLITRQNGESCVLMSLEEYNSLEETAYLLRSPKNARRLMDSIESLQSGNGTERD
IIE

Nucleotide

• Length: 252 bp

>AT123237 NZ_CP038855:c27692-27441 [Pantoea vagans]
ATGAGAGCAATCAGTTACAGCGAAGCCCGACAAAATCTGTCTGCCACTATGGTTCAGACGGTTGAAGATAAAGCGCCGGT
ACTAATCACCCGCCAGAACGGTGAATCCTGCGTGCTGATGTCGCTTGAAGAATATAACTCACTGGAAGAGACAGCCTACC
TGCTGCGGTCACCTAAGAATGCTCGCAGGTTAATGGATTCCATCGAAAGTCTGCAAAGCGGTAACGGTACTGAAAGGGAT
ATTATTGAGTGA