Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 34485..35136 Replicon plasmid pVag1
Accession NZ_CP038854
Organism Pantoea vagans strain LMG 24199

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EGO56_RS19060 Protein ID WP_135910638.1
Coordinates 34485..34829 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EGO56_RS19065 Protein ID WP_033735285.1
Coordinates 34822..35136 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGO56_RS19040 30826..31296 + 471 WP_135910634.1 GNAT family N-acetyltransferase -
EGO56_RS19045 31400..32278 + 879 WP_135910635.1 23S rRNA pseudouridine(2604) synthase RluF -
EGO56_RS19050 32333..33391 - 1059 WP_135910636.1 SDR family oxidoreductase -
EGO56_RS19055 33489..34394 + 906 WP_135910637.1 LysR family transcriptional regulator -
EGO56_RS19060 34485..34829 + 345 WP_135910638.1 toxin Toxin
EGO56_RS19065 34822..35136 + 315 WP_033735285.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
EGO56_RS19070 35350..36021 + 672 WP_135910639.1 hypothetical protein -
EGO56_RS19075 36114..36965 - 852 WP_135910640.1 MBL fold metallo-hydrolase -
EGO56_RS19080 37112..37993 + 882 WP_135910641.1 LysR family transcriptional regulator -
EGO56_RS19085 38030..38449 + 420 WP_135910642.1 VOC family protein -
EGO56_RS19090 38921..39223 + 303 WP_135910643.1 type 1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla / vipA/tssB / vipB/tssC / vasE/tssK / dotU/tssL / hcp/tssD / clpV/tssH / vgrG/tssI / KPHS_23120 / icmF/tssM / tssF / tssG / sciN/tssJ / iroN 1..559692 559692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin MqsA/HigA-2

(19-100)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13544.30 Da        Isoelectric Point: 9.2747

>T123234 WP_135910638.1 NZ_CP038854:34485-34829 [Pantoea vagans]
MDALFIELSSFQKYRADYLNDDQYRRFQNMLLADPEKGDVIPDTGGLRKVRFRDERRHKGARGGIRIIYYWTDEQGQFIL
FTIYDKDQRDDLTKQQRDALATALNVIKKGLRHD

Download         Length: 345 bp

>T123234 NZ_CP038854:34485-34829 [Pantoea vagans]
ATGGACGCATTATTCATCGAGCTTTCCAGCTTTCAGAAATACCGGGCTGACTATCTGAATGATGATCAGTATCGGCGATT
TCAAAATATGTTGCTGGCTGACCCTGAAAAGGGTGATGTGATACCCGATACCGGCGGACTGCGTAAGGTTCGTTTCAGGG
ATGAGCGCCGACACAAGGGGGCCAGAGGTGGCATCAGGATTATCTATTACTGGACGGACGAACAAGGCCAGTTCATCCTG
TTTACCATCTACGATAAAGACCAACGCGACGATCTTACGAAGCAGCAGCGTGATGCCCTGGCGACCGCGCTGAATGTGAT
CAAAAAAGGGTTGAGACATGACTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12091.91 Da        Isoelectric Point: 9.9125

>AT123234 WP_033735285.1 NZ_CP038854:34822-35136 [Pantoea vagans]
MTERDIFSELMTGMQELKDHQEGKITLKRYKVTKRAPVTIAPQELRDVREKLNLSQAVFAHYLHTGETTYQNWEQGRARP
NAQAVLLIRMVQQNPETLKTLAQL

Download         Length: 315 bp

>AT123234 NZ_CP038854:34822-35136 [Pantoea vagans]
ATGACTGAACGCGATATTTTCAGTGAACTGATGACGGGTATGCAGGAGCTTAAGGATCATCAGGAGGGCAAAATCACGCT
CAAGCGGTATAAGGTCACGAAGCGTGCTCCTGTCACTATTGCGCCGCAGGAGTTGCGCGACGTACGCGAAAAACTCAACC
TCTCCCAGGCCGTTTTCGCCCATTATCTCCACACTGGCGAGACGACCTATCAGAACTGGGAGCAGGGCAGAGCCAGACCT
AACGCCCAGGCTGTATTATTAATTCGCATGGTGCAGCAGAACCCTGAAACGCTAAAGACGCTCGCGCAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References