123233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3764574..3765226 Replicon chromosome
Accession NZ_CP038853
Organism Pantoea vagans strain LMG 24199

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EGO56_RS17620 Protein ID WP_135910396.1
Coordinates 3764574..3764930 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EGO56_RS17625 Protein ID WP_135910397.1
Coordinates 3764927..3765226 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGO56_RS17605 3760307..3762091 - 1785 WP_135910394.1 GMC family oxidoreductase -
EGO56_RS17610 3762094..3762828 - 735 WP_135910395.1 gluconate 2-dehydrogenase subunit 3 family protein -
EGO56_RS17615 3763104..3764345 + 1242 WP_033781572.1 peptide antibiotic transporter SbmA -
EGO56_RS17620 3764574..3764930 + 357 WP_135910396.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGO56_RS17625 3764927..3765226 + 300 WP_135910397.1 XRE family transcriptional regulator Antitoxin
EGO56_RS17630 3765335..3766378 - 1044 WP_135910398.1 YncE family protein -
EGO56_RS17635 3766577..3766786 - 210 WP_009092571.1 DUF1471 domain-containing protein -
EGO56_RS17640 3766999..3768186 - 1188 WP_135910399.1 MFS transporter -
EGO56_RS17645 3768291..3769256 + 966 WP_013359813.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13934.01 Da        Isoelectric Point: 9.3310

>T123233 WP_135910396.1 NZ_CP038853:3764574-3764930 [Pantoea vagans]
MWTVLLSARFESWLSEQEQALQEKVLADLTMLKIYGPDLPRPYADTLKGSQYKNMKELRVQFSGRPIRAFYAFDYVRRAI
VLCAGDKSQDKRFYSRMIRIADNEFSAWLAELEKENNR

Download         Length: 357 bp

>T123233 NZ_CP038853:3764574-3764930 [Pantoea vagans]
ATGTGGACGGTGTTATTAAGTGCGAGGTTTGAAAGCTGGTTAAGCGAGCAGGAACAAGCCCTGCAGGAAAAAGTGTTAGC
TGACCTGACAATGTTAAAAATTTACGGCCCTGATTTGCCTCGTCCTTATGCTGATACTCTTAAGGGATCGCAGTATAAGA
ACATGAAAGAACTACGCGTACAGTTTTCAGGAAGGCCCATCCGGGCATTTTATGCATTTGATTATGTCCGCCGGGCTATC
GTGTTGTGTGCGGGCGATAAGAGTCAGGACAAACGTTTCTACAGTCGAATGATACGTATTGCTGACAATGAATTTTCAGC
CTGGCTTGCTGAACTGGAGAAGGAAAATAATCGATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11011.76 Da        Isoelectric Point: 4.8604

>AT123233 WP_135910397.1 NZ_CP038853:3764927-3765226 [Pantoea vagans]
MRTLDEVIAGFSPESQARIQEMSDEMVLEIGLQMIREELQLSQKNLAEAMGVRQPAVAQIEQRGNEIKVATLKRYIEAMG
GKLSLNVELPTGKSVAFHI

Download         Length: 300 bp

>AT123233 NZ_CP038853:3764927-3765226 [Pantoea vagans]
ATGAGAACTTTAGATGAGGTTATTGCTGGCTTCTCCCCGGAGAGTCAGGCGCGAATCCAGGAAATGTCTGATGAAATGGT
CTTAGAAATCGGACTGCAGATGATCCGTGAAGAACTTCAGCTATCACAAAAAAACCTCGCTGAGGCTATGGGAGTGCGTC
AGCCTGCCGTTGCTCAGATTGAGCAGCGCGGGAATGAGATTAAGGTTGCTACGCTCAAACGCTATATCGAAGCGATGGGC
GGGAAACTGAGCCTGAATGTGGAACTGCCGACCGGAAAAAGCGTGGCGTTTCACATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References