Detailed information of TA system TA123229

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1532587..1533247
• Replicon: chromosome
• Accession: NZ_CP038853
• Organism: Pantoea vagans strain LMG 24199

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: EGO56_RS07095
• Protein ID: WP_135908211.1
• Coordinates: 1532587..1532940 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: EGO56_RS07100
• Protein ID: WP_033733169.1
• Coordinates: 1532945..1533247 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGO56_RS07080	1528190..1528471	+	282	WP_135908208.1	hypothetical protein	-
EGO56_RS07085	1528625..1530787	-	2163	WP_135908209.1	ferric-rhodotorulic acid/ferric-coprogen receptor FhuE	-
EGO56_RS07090	1531213..1532301	+	1089	WP_135908210.1	hypothetical protein	-
EGO56_RS07095	1532587..1532940	+	354	WP_135908211.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGO56_RS07100	1532945..1533247	+	303	WP_033733169.1	XRE family transcriptional regulator	Antitoxin
EGO56_RS07110	1533918..1534841	+	924	WP_013358384.1	sugar ABC transporter substrate-binding protein	-
EGO56_RS07115	1534874..1536358	+	1485	WP_135908212.1	sugar ABC transporter ATP-binding protein	-
EGO56_RS07120	1536382..1537407	+	1026	WP_179291192.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-79)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13585.72 Da
• Isoelectric Point: 9.8996

>T123229 WP_135908211.1 NZ_CP038853:1532587-1532940 [Pantoea vagans]
VWMIKTTERFDLWFTLLNDSDRACVLAALMVLREKGPGLSRPYADTIKGSAYINMKELRIQSRGDPIRAFFAFDPNRTAI
VLCAGNKAGNEKRFYREMLPVADREFTHWLKSFNHKE

Nucleotide

• Length: 354 bp

>T123229 NZ_CP038853:1532587-1532940 [Pantoea vagans]
GTGTGGATGATTAAAACGACAGAGCGGTTTGATCTCTGGTTTACGTTGCTTAATGACAGCGATCGCGCCTGCGTTCTGGC
TGCATTGATGGTGTTGCGGGAAAAGGGGCCGGGATTAAGCCGACCCTATGCGGATACGATTAAAGGTTCCGCTTATATCA
ATATGAAAGAGTTACGTATCCAGAGCCGCGGCGACCCAATAAGGGCTTTCTTTGCTTTTGACCCGAACCGCACGGCAATT
GTGCTGTGTGCCGGTAATAAGGCGGGCAATGAAAAGCGATTTTATCGGGAGATGCTTCCGGTTGCCGATCGGGAATTCAC
ACACTGGCTAAAAAGCTTTAACCATAAGGAGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10911.69 Da
• Isoelectric Point: 5.7134

>AT123229 WP_033733169.1 NZ_CP038853:1532945-1533247 [Pantoea vagans]
MGRTLEQLIADEKPEVVADAQAMATEILLNIHLAELREKVQKTQVEMAQALGITQPTVAGMEKPGRDLKLSTLKRYVDAA
GGKLRLVVELPDGSHYGFVV

Nucleotide

• Length: 303 bp

>AT123229 NZ_CP038853:1532945-1533247 [Pantoea vagans]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAACCGGAAGTCGTTGCCGACGCACAGGCCATGGCGACCGAAAT
CCTGCTCAACATTCACCTTGCCGAGCTGCGTGAGAAAGTGCAGAAAACGCAGGTCGAAATGGCGCAGGCGCTGGGCATCA
CACAGCCGACTGTGGCGGGTATGGAAAAGCCGGGGCGTGACCTGAAGCTTTCCACGCTCAAACGCTATGTGGATGCGGCA
GGGGGGAAACTGCGGCTGGTGGTGGAGCTGCCGGATGGTTCCCACTACGGGTTCGTGGTGTAA