Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2453334..2453518 Replicon chromosome
Accession NZ_CP038819
Organism Staphylococcus aureus strain O82

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag SaO82_RS12500 Protein ID WP_000482647.1
Coordinates 2453411..2453518 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2453334..2453394 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO82_RS12475 2448788..2448955 - 168 WP_031901225.1 hypothetical protein -
SaO82_RS12485 2449186..2450919 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
SaO82_RS12490 2450944..2452707 - 1764 WP_001064823.1 ABC transporter ATP-binding protein/permease -
- 2453334..2453394 + 61 - - Antitoxin
SaO82_RS12500 2453411..2453518 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
SaO82_RS12505 2453652..2454038 - 387 WP_000779350.1 flippase GtxA -
SaO82_RS12510 2454306..2455448 + 1143 WP_001176867.1 glycerate kinase -
SaO82_RS12515 2455508..2456167 + 660 WP_000831298.1 membrane protein -
SaO82_RS12520 2456350..2457561 + 1212 WP_001191927.1 multidrug effflux MFS transporter -
SaO82_RS12525 2457684..2458157 - 474 WP_000456488.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T123224 WP_000482647.1 NZ_CP038819:c2453518-2453411 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T123224 NZ_CP038819:c2453518-2453411 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT123224 NZ_CP038819:2453334-2453394 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References