Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 2050399..2051043 | Replicon | chromosome |
| Accession | NZ_CP038817 | ||
| Organism | Haemophilus parahaemolyticus strain NEB129 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | I2NMH5 |
| Locus tag | E5Q53_RS09905 | Protein ID | WP_005705597.1 |
| Coordinates | 2050738..2051043 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | E5Q53_RS09900 | Protein ID | WP_100208016.1 |
| Coordinates | 2050399..2050722 (-) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E5Q53_RS09860 | 2045595..2046251 | - | 657 | WP_005705604.1 | helix-turn-helix domain-containing protein | - |
| E5Q53_RS09865 | 2046370..2046555 | + | 186 | WP_005705808.1 | Cro/Cl family transcriptional regulator | - |
| E5Q53_RS09870 | 2046629..2047369 | + | 741 | WP_050855299.1 | Rha family transcriptional regulator | - |
| E5Q53_RS10315 | 2047366..2047755 | + | 390 | Protein_1889 | helix-turn-helix domain-containing protein | - |
| E5Q53_RS09880 | 2048142..2048984 | + | 843 | WP_005705766.1 | ATP-binding protein | - |
| E5Q53_RS09885 | 2048984..2049436 | + | 453 | WP_005705767.1 | DUF1367 family protein | - |
| E5Q53_RS09890 | 2049465..2050097 | - | 633 | WP_005705858.1 | Bro-N domain-containing protein | - |
| E5Q53_RS09900 | 2050399..2050722 | - | 324 | WP_100208016.1 | HigA family addiction module antidote protein | Antitoxin |
| E5Q53_RS09905 | 2050738..2051043 | - | 306 | WP_005705597.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| E5Q53_RS09910 | 2051141..2051575 | - | 435 | WP_005705607.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| E5Q53_RS09915 | 2051635..2051808 | - | 174 | WP_100208013.1 | mRNA interferase | - |
| E5Q53_RS10255 | 2051909..2052073 | + | 165 | WP_005705635.1 | hypothetical protein | - |
| E5Q53_RS09920 | 2052066..2052644 | + | 579 | WP_005705657.1 | recombination protein NinG | - |
| E5Q53_RS09925 | 2052637..2053026 | + | 390 | WP_005705737.1 | hypothetical protein | - |
| E5Q53_RS09930 | 2053159..2053413 | + | 255 | WP_039862994.1 | hypothetical protein | - |
| E5Q53_RS09935 | 2053400..2053954 | + | 555 | WP_005705704.1 | lysozyme | - |
| E5Q53_RS09940 | 2053927..2054268 | + | 342 | WP_005705840.1 | DUF2570 family protein | - |
| E5Q53_RS09950 | 2054781..2055038 | - | 258 | WP_005705748.1 | hypothetical protein | - |
| E5Q53_RS09955 | 2055040..2055276 | - | 237 | WP_039862992.1 | helix-turn-helix domain-containing protein | - |
| E5Q53_RS09960 | 2055264..2055659 | - | 396 | WP_005705606.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | msbA | 1959533..2079623 | 120090 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11870.57 Da Isoelectric Point: 7.3969
>T123213 WP_005705597.1 NZ_CP038817:c2051043-2050738 [Haemophilus parahaemolyticus]
MINLTASHFRDDYLYRFYQFGESHSKIPANLTNVLARKLDMINAAENINDLRVPPANHLELLEPKENKIYSIRVNKQYRL
IFKFENGTLSDLFLDPHTYAL
MINLTASHFRDDYLYRFYQFGESHSKIPANLTNVLARKLDMINAAENINDLRVPPANHLELLEPKENKIYSIRVNKQYRL
IFKFENGTLSDLFLDPHTYAL
Download Length: 306 bp
>T123213 NZ_CP038817:c2051043-2050738 [Haemophilus parahaemolyticus]
ATGATTAACCTAACCGCCTCACATTTTCGTGATGATTATCTCTACCGCTTTTACCAATTTGGCGAAAGTCACAGTAAAAT
TCCTGCGAACCTAACCAATGTGCTTGCTCGCAAATTGGATATGATCAACGCAGCCGAAAACATCAACGATTTACGAGTGC
CACCAGCTAACCACCTTGAACTACTCGAACCGAAAGAGAATAAAATCTATTCCATTCGAGTGAATAAACAGTACCGTCTG
ATTTTCAAATTTGAAAACGGCACACTGTCCGATTTATTTTTAGATCCGCATACATACGCACTATAA
ATGATTAACCTAACCGCCTCACATTTTCGTGATGATTATCTCTACCGCTTTTACCAATTTGGCGAAAGTCACAGTAAAAT
TCCTGCGAACCTAACCAATGTGCTTGCTCGCAAATTGGATATGATCAACGCAGCCGAAAACATCAACGATTTACGAGTGC
CACCAGCTAACCACCTTGAACTACTCGAACCGAAAGAGAATAAAATCTATTCCATTCGAGTGAATAAACAGTACCGTCTG
ATTTTCAAATTTGAAAACGGCACACTGTCCGATTTATTTTTAGATCCGCATACATACGCACTATAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12177.98 Da Isoelectric Point: 6.4645
>AT123213 WP_100208016.1 NZ_CP038817:c2050722-2050399 [Haemophilus parahaemolyticus]
ITERKPTSVGEILLEEFLEPLNLKVGDLAQILDVHRNTASSLINNNTRISLEMAVKLSKAFSTSPEFWLNLQTAVDLWEL
NHNKRFQQTLANVRVANQWQAMPAFAM
ITERKPTSVGEILLEEFLEPLNLKVGDLAQILDVHRNTASSLINNNTRISLEMAVKLSKAFSTSPEFWLNLQTAVDLWEL
NHNKRFQQTLANVRVANQWQAMPAFAM
Download Length: 324 bp
>AT123213 NZ_CP038817:c2050722-2050399 [Haemophilus parahaemolyticus]
ATTACAGAACGCAAACCAACCAGTGTAGGCGAAATCCTACTAGAAGAATTTTTAGAACCACTTAACTTAAAAGTAGGCGA
TTTAGCTCAAATTCTTGACGTACATCGCAACACCGCCAGCAGCCTAATCAATAACAACACTCGCATTAGCTTAGAAATGG
CGGTTAAACTCTCGAAAGCGTTCAGTACCAGCCCTGAATTTTGGCTGAACCTACAAACTGCCGTGGATTTATGGGAACTC
AACCACAACAAACGCTTTCAGCAAACATTAGCGAACGTGCGAGTAGCGAATCAATGGCAAGCAATGCCAGCTTTTGCAAT
GTAA
ATTACAGAACGCAAACCAACCAGTGTAGGCGAAATCCTACTAGAAGAATTTTTAGAACCACTTAACTTAAAAGTAGGCGA
TTTAGCTCAAATTCTTGACGTACATCGCAACACCGCCAGCAGCCTAATCAATAACAACACTCGCATTAGCTTAGAAATGG
CGGTTAAACTCTCGAAAGCGTTCAGTACCAGCCCTGAATTTTGGCTGAACCTACAAACTGCCGTGGATTTATGGGAACTC
AACCACAACAAACGCTTTCAGCAAACATTAGCGAACGTGCGAGTAGCGAATCAATGGCAAGCAATGCCAGCTTTTGCAAT
GTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|