Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1566452..1566964 Replicon chromosome
Accession NZ_CP038808
Organism Streptococcus pneumoniae strain R6CIB17

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag E5Q10_RS08210 Protein ID WP_000924721.1
Coordinates 1566452..1566706 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag E5Q10_RS08215 Protein ID WP_000388572.1
Coordinates 1566710..1566964 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5Q10_RS08195 1563553..1563867 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
E5Q10_RS08200 1563892..1564518 - 627 WP_000775044.1 guanylate kinase -
E5Q10_RS08205 1564648..1566261 - 1614 WP_000404940.1 ribonuclease Y -
E5Q10_RS08210 1566452..1566706 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
E5Q10_RS08215 1566710..1566964 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E5Q10_RS08220 1567202..1568299 - 1098 WP_000156355.1 nucleotidyltransferase -
E5Q10_RS08225 1568309..1569055 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
E5Q10_RS08230 1569158..1569511 - 354 WP_001003001.1 ribosome silencing factor -
E5Q10_RS08235 1569524..1570024 - 501 WP_000844717.1 cysteine hydrolase -
E5Q10_RS08240 1570025..1570618 - 594 WP_000121655.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
E5Q10_RS08245 1570618..1571247 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
E5Q10_RS08250 1571299..1571610 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T123197 WP_000924721.1 NZ_CP038808:c1566706-1566452 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T123197 NZ_CP038808:c1566706-1566452 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT123197 WP_000388572.1 NZ_CP038808:c1566964-1566710 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT123197 NZ_CP038808:c1566964-1566710 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTACGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References