Detailed information of TA system TA123174

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-Phd
• Location: 2131281..2131783
• Replicon: chromosome
• Accession: NZ_CP038801
• Organism: Treponema denticola strain ATCC 700771

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: E4N77_RS10060
• Protein ID: WP_255802957.1
• Coordinates: 2131523..2131783 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A0E2ECR9
• Locus tag: E4N77_RS10055
• Protein ID: WP_002672677.1
• Coordinates: 2131281..2131523 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N77_RS10030 (E4N77_10335)	2126667..2128214	-	1548	WP_255802949.1	fibronectin type III domain-containing protein	-
E4N77_RS10035 (E4N77_10340)	2128406..2129686	-	1281	WP_255802950.1	amino acid permease	-
E4N77_RS10040 (E4N77_10345)	2129739..2130464	-	726	WP_255802951.1	gamma-glutamyl-gamma-aminobutyrate hydrolase family protein	-
E4N77_RS10045 (E4N77_10350)	2130721..2130954	+	234	WP_002692434.1	hypothetical protein	-
E4N77_RS10050 (E4N77_10355)	2130947..2131219	+	273	WP_255802955.1	type II toxin-antitoxin system RelE/ParE family toxin	-
E4N77_RS10055 (E4N77_10360)	2131281..2131523	+	243	WP_002672677.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E4N77_RS10060 (E4N77_10365)	2131523..2131783	+	261	WP_255802957.1	Txe/YoeB family addiction module toxin	Toxin
E4N77_RS10065 (E4N77_10370)	2131810..2132091	-	282	WP_255802959.1	helix-turn-helix transcriptional regulator	-
E4N77_RS10070 (E4N77_10375)	2132293..2132721	-	429	WP_255802961.1	PIN domain-containing protein	-
E4N77_RS10075 (E4N77_10380)	2132714..2132953	-	240	WP_255802962.1	DUF6364 family protein	-
E4N77_RS10080 (E4N77_10385)	2133188..2134321	+	1134	WP_255802963.1	tRNA guanosine(34) transglycosylase Tgt	-
E4N77_RS10085 (E4N77_10390)	2134388..2135587	+	1200	WP_255802964.1	HEAT repeat domain-containing protein	-
E4N77_RS10090	2135702..2135854	+	153	WP_255802965.1	hypothetical protein	-
E4N77_RS10095 (E4N77_10395)	2135857..2136672	+	816	WP_255802966.1	DNA repair protein RecO C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10294.03 Da
• Isoelectric Point: 10.3167

>T123174 WP_255802957.1 NZ_CP038801:2131523-2131783 [Treponema denticola]
MWTVVYSKQAAKDSKKIEQSNLKESVKRLIEVLKNDPFQNPPPYEKLIGDLTGKFSRRINLQHRLVYEVFGKEMIVRVLR
MWTHYE

Nucleotide

• Length: 261 bp

>T123174 NZ_CP038801:2131523-2131783 [Treponema denticola]
ATGTGGACTGTAGTTTATTCAAAACAAGCTGCAAAAGACAGTAAAAAAATTGAACAATCCAATTTAAAAGAAAGCGTTAA
GAGATTGATAGAAGTTTTGAAAAACGATCCATTTCAAAATCCGCCGCCTTATGAAAAATTAATAGGTGATTTAACAGGAA
AGTTTTCAAGAAGAATAAATCTTCAGCATCGGCTTGTGTATGAAGTTTTTGGAAAAGAAATGATTGTTCGTGTTCTTCGA
ATGTGGACTCATTATGAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9175.34 Da
• Isoelectric Point: 4.1317

>AT123174 WP_002672677.1 NZ_CP038801:2131281-2131523 [Treponema denticola]
MTIMTATAARTNLYNLIDRTKEFHEPIIISGKRNNAVLISEDDWNSIQETLYLCSIPGMRESILEASEESLEESVKELDW

Nucleotide

• Length: 243 bp

>AT123174 NZ_CP038801:2131281-2131523 [Treponema denticola]
ATGACGATAATGACAGCAACAGCAGCTAGAACAAATTTATATAATCTTATTGACCGGACAAAAGAATTTCATGAACCGAT
TATTATTTCAGGAAAAAGAAATAATGCAGTATTGATATCGGAAGATGATTGGAATTCAATTCAGGAAACATTATATTTAT
GTTCTATTCCGGGAATGAGAGAATCTATTCTTGAAGCAAGTGAAGAATCTTTGGAAGAAAGCGTAAAGGAACTGGATTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A0E2ECR9