Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3424155..3424815 Replicon chromosome
Accession NZ_CP038662
Organism Serratia nematodiphila strain DH-S01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E5D60_RS16315 Protein ID WP_135638348.1
Coordinates 3424462..3424815 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E5D60_RS16310 Protein ID WP_085336769.1
Coordinates 3424155..3424457 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5D60_RS16290 3419782..3420696 - 915 WP_048324303.1 branched-chain amino acid ABC transporter permease -
E5D60_RS16295 3420820..3421938 - 1119 WP_033632602.1 branched-chain amino acid ABC transporter substrate-binding protein -
E5D60_RS16305 3422521..3423729 - 1209 WP_033632601.1 aldose 1-epimerase family protein -
E5D60_RS16310 3424155..3424457 - 303 WP_085336769.1 XRE family transcriptional regulator Antitoxin
E5D60_RS16315 3424462..3424815 - 354 WP_135638348.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E5D60_RS16320 3425252..3426547 + 1296 WP_135638350.1 MFS transporter -
E5D60_RS16325 3426574..3427380 + 807 WP_060559892.1 substrate-binding domain-containing protein -
E5D60_RS16330 3427355..3428254 - 900 WP_049278342.1 LysR family transcriptional regulator -
E5D60_RS16335 3428359..3428724 - 366 WP_004935528.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13620.62 Da        Isoelectric Point: 9.0587

>T123111 WP_135638348.1 NZ_CP038662:c3424815-3424462 [Serratia nematodiphila]
VWEIKTTDAFDHWFRSLSDADRVCVLAALMVLREKGPGLPRLYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMLQIADREFTNWLNTLNEKE

Download         Length: 354 bp

>T123111 NZ_CP038662:c3424815-3424462 [Serratia nematodiphila]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCACTCAGCGATGCCGACCGGGTCTGCGTGCTTGC
TGCATTGATGGTTCTGCGGGAAAAAGGGCCCGGCTTGCCCAGGCTCTATGCCGATACGGTTAAAGGCTCGCGTTACAGCA
ACATGAAAGAGCTGCGTATTCAGAGCCGTGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAGCGTTTTTACGATCGAATGCTGCAGATTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11126.02 Da        Isoelectric Point: 6.4738

>AT123111 WP_085336769.1 NZ_CP038662:c3424457-3424155 [Serratia nematodiphila]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFML

Download         Length: 303 bp

>AT123111 NZ_CP038662:c3424457-3424155 [Serratia nematodiphila]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTCGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATTGAACTGCCGGACGGTTCGCACTACGAATTTATGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References