Detailed information of TA system TA123092

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 583107..583692
• Replicon: chromosome
• Accession: NZ_CP038644
• Organism: Acinetobacter baumannii strain ACN21

Toxin (Protein)

• Gene name: higB
• Uniprot ID: N9CJF7
• Locus tag: E5D09_RS02810
• Protein ID: WP_000897307.1
• Coordinates: 583107..583427 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: E5D09_RS02815
• Protein ID: WP_000369781.1
• Coordinates: 583420..583692 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5D09_RS02775	578862..579176	-	315	WP_004728120.1	BrnA antitoxin family protein	-
E5D09_RS02780	579163..579450	-	288	WP_000438825.1	BrnT family toxin	-
E5D09_RS02785	579719..580249	-	531	WP_000172759.1	hypothetical protein	-
E5D09_RS02790	580398..580700	+	303	WP_000286964.1	type II toxin-antitoxin system RelE/ParE family toxin	-
E5D09_RS02795	580701..580982	+	282	WP_000985609.1	putative addiction module antidote protein	-
E5D09_RS02800	581062..581481	-	420	WP_001180106.1	SMI1/KNR4 family protein	-
E5D09_RS02805	581644..582978	+	1335	WP_033917544.1	ISNCY family transposase	-
E5D09_RS02810	583107..583427	+	321	WP_000897307.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E5D09_RS02815	583420..583692	+	273	WP_000369781.1	helix-turn-helix domain-containing protein	Antitoxin
E5D09_RS02820	584185..585646	+	1462	Protein_555	ABC-F type ribosomal protection protein Msr(E)	-
E5D09_RS02825	585715..586599	+	885	Protein_556	Mph(E) family macrolide 2'-phosphotransferase	-
E5D09_RS02830	586691..587457	-	767	Protein_557	IS4-like element ISAba1 family transposase	-
E5D09_RS02835	587522..588226	+	705	WP_001067790.1	IS6-like element IS1008 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	msr(E) / mph(E)	-	578031..591724	13693
	-	inside	IScluster/Tn	msr(E) / mph(E)	-	576802..588226	11424

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12187.95 Da
• Isoelectric Point: 7.1639

>T123092 WP_000897307.1 NZ_CP038644:583107-583427 [Acinetobacter baumannii]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILHQLVKEQFHG

Nucleotide

• Length: 321 bp

>T123092 NZ_CP038644:583107-583427 [Acinetobacter baumannii]
ATGTTATTTATTGAAACCAGCATCTTTACCAAGCAAATTAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAGCA
AGATCTTTTGGTACAGCCTGATAGAGGTGACCTAATCAAGAATGGCGGTGGTATTCGCAAAGTACGTTGTGCTCAAGGTA
ACAAAGGGAAAAGTGGTGGGATACGGGTGATTTATTATTGGGTCACCGAGGATGATCAGATCTTTTTCTTAGTGGCTTAT
CCAAAATCAGTAAAAGATAATTTAACAGATAAGGAAACCGCCATTCTGCACCAACTCGTGAAGGAGCAATTTCATGGATA
A

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10149.61 Da
• Isoelectric Point: 8.6582

>AT123092 WP_000369781.1 NZ_CP038644:583420-583692 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Nucleotide

• Length: 273 bp

>AT123092 NZ_CP038644:583420-583692 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATCAAAGAAGCTGGAGCTATCAAACGTAAAGAAGTTAAAGCAAG
CCGAGTTACAGAACTCGAATTGCCTGATATTAAAGAAGTACGTGAAAAAACTGGCTTGAGCCAAAATGAATTTGCTGCAC
GTCTACATATTAGCCCCCGTACCCTGCAAAATTGGGAACAGGGACGACGCTATCCAACTGGACCAGCAGCTACATTGATT
CGAATTTTAGATGCTCACCCAAGCCTTATTTGA

Structures

Toxin

• AlphaFold DB: A0A0A8TMZ3