Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2565161..2565684 Replicon chromosome
Accession NZ_CP038612
Organism Staphylococcus aureus strain O268

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag SaO268_RS13440 Protein ID WP_000074048.1
Coordinates 2565161..2565427 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag SaO268_RS13445 Protein ID WP_000587617.1
Coordinates 2565427..2565684 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO268_RS13420 2560371..2561558 - 1188 WP_000026189.1 MFS transporter -
SaO268_RS13425 2561953..2562729 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
SaO268_RS13430 2562722..2563384 - 663 WP_000923508.1 ATP-binding cassette domain-containing protein -
SaO268_RS13435 2563729..2564805 - 1077 WP_001076674.1 M42 family metallopeptidase -
SaO268_RS13440 2565161..2565427 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
SaO268_RS13445 2565427..2565684 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SaO268_RS13455 2566045..2566512 + 468 WP_000732083.1 YehR family lipoprotein -
SaO268_RS13460 2566668..2568245 - 1578 WP_065315873.1 FMN-binding glutamate synthase family protein -
SaO268_RS13465 2568439..2569188 + 750 WP_000072455.1 CPBP family intramembrane metalloprotease -
SaO268_RS13470 2569412..2570605 - 1194 WP_000675398.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T123075 WP_000074048.1 NZ_CP038612:c2565427-2565161 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T123075 NZ_CP038612:c2565427-2565161 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT123075 WP_000587617.1 NZ_CP038612:c2565684-2565427 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT123075 NZ_CP038612:c2565684-2565427 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References